S. Johnson

Increased vowel contrast and intelligibility in connected speech induced by sensorimotor adaptation

This paper uses sensorimotor adaptation to increase vowel contrast and intelligibility in speech, showing that these changes persist and improve communication.

γ-aminobutyric acid receptor B signaling drives glioblastoma in females in an immune-dependent manner

This study shows GABA receptor B signaling promotes GBM growth in females through immune mechanisms, with sex-specific effects on survival and treatment outcomes.

A novel feeding mechanism: Sunbirds drink nectar via intralingual suction

This study reveals that sunbirds use intralingual suction to drink nectar, a unique mechanism not found in other animals.

Genotypic and phenotypic characterization of Enterococcus faecalis isolates from periprosthetic joint infections

This study characterizes genotypic and phenotypic features of Enterococcus faecalis isolates from periprosthetic joint infections, revealing genetic and phenotypic heterogeneity.

Oblique Line Scan Illumination Enables Expansive, Accurate and Sensitive Single Protein Measurements in Solution and in Living Cells

This paper introduces Oblique Line Scan (OLS) illumination to enhance single-molecule tracking in living cells and solution, enabling high-throughput and sensitive protein dynamics measurements.

Tumor cell-derived spermidine promotes a pro-tumorigenic immune microenvironment in glioblastoma via CD8+ T cell inhibition

This study shows that spermidine, a metabolite from glioblastoma cells, suppresses CD8+ T cell function, promoting tumor growth and poor patient outcomes.

Multiple Intermediates in the Detergent-Induced Fusion of Lipid Vesicles

This study identifies multiple intermediates in detergent-induced vesicle fusion using FRET and single-vesicle analysis, revealing a multi-step mechanism involving permeabilization, docking, hemi-fusion, and lipid mixing.

No general effects of advancing male age on ejaculates: a meta-analysis across the animal kingdom

This study conducts a meta-analysis of 1814 effect sizes from 379 studies to assess male reproductive senescence across species, finding no general pattern and highlighting taxonomic and methodological factors influencing results.

Prioritizing Annotated miRNAs: Only a Small Percentage are Candidates for Biological Regulation

The paper identifies that only 2% of annotated miRNAs are likely to function as robust gene regulators based on their abundance, DROSHA dependence, and association with AGO proteins.

Bordetella Spp. Utilize T3SS To Promote Secretion of IL1RA Leading to Long-Term Per-sistent Infections

This study shows Bordetella spp. use T3SS to secrete IL1RA, promoting persistent infections and suggesting IL1RA as a therapeutic target for whooping cough.

SAMHD1 controls nucleoside-based cancer therapeutics, deoxyguanosine toxicity, and inflammation

This study shows that SAMHD1 knockout affects nucleoside analogue sensitivity, deoxyguanosine toxicity, and inflammation in macrophages, linking it to Acardi-Goutieres Syndrome and cancer therapies.

Sex-specific T cell exhaustion drives differential immune responses in glioblastoma

This study shows male T cells are more exhausted in glioblastoma, leading to worse outcomes and better response to anti-PD1 treatment compared to females.

Mammary Tissue-Derived Extracellular Matrix Hydrogels Reveal the Role of Irradiation in Driving a Pro-Tumor and Immunosuppressive Microenvironment

This study shows that irradiated mammary tissue ECM hydrogels promote TNBC cell proliferation, invasion, and immunosuppression by altering ECM composition and macrophage polarization.

Tween-20 induces the structural remodelling of single lipid vesicles

This study investigates how Tween-20 interacts with lipid vesicles, revealing stepwise structural changes even below critical micellar concentration.

Discovery of a SARS-CoV-2 Broadly-Acting Neutralizing Antibody with Activity against Omicron and Omicron + R346K Variants

This paper identifies a broadly neutralizing antibody, STI-9167, effective against SARS-CoV-2 variants including Omicron and Omicron + R346K, and describes its development for clinical trials.

Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses

This study shows that Omicron-B.1.1.529 has extensive mutations in Spike that reduce neutralization by antibodies from vaccinated and previously infected individuals, and escape most monoclonal antibodies.

Oral and intranasal Ad5 SARS-CoV-2 vaccines decrease disease and viral transmission in a golden hamster model

This study shows oral and intranasal Ad5 SARS-CoV-2 vaccines reduce disease severity and viral transmission in golden hamsters.

Distinct cell adhesion signature defines glioblastoma myeloid-derived suppressor cell subsets

The paper identifies distinct cell adhesion signatures in glioblastoma myeloid-derived suppressor cell subsets, showing that monocytic MDSCs drive tumor growth through enhanced integrin β1 expression.

WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma

This study identifies WDR5 as an essential epigenetic regulator in therapy-resistant glioblastoma cancer stem cells and shows that WDR5 inhibitors disrupt CSC maintenance and tumor growth.

Targeting the Cx26/NANOG/Focal Adhesion Kinase Complex via Cell Penetrating Peptides in Triple Negative Breast Cancers

This study demonstrates that a cell-penetrating peptide targeting the Cx26/NANOG/FAK complex inhibits tumor growth and alters NANOG activity in triple-negative breast cancer.

A Panel of Diverse Pseudomonas aeruginosa Clinical Isolates for Research and Development

The paper describes a panel of 100 diverse Pseudomonas aeruginosa clinical isolates selected to represent genetic and antibiotic susceptibility diversity for research and development.

Targeting properdin - Structure and function of a novel family of tick-derived complement inhibitors

This study identifies and characterizes a novel family of tick-derived complement inhibitors, CirpA, which bind to properdin and inhibit complement activation.

Paternal hypoxia exposure primes offspring for increased hypoxia resistance

This study shows that paternal hypoxia exposure increases offspring hypoxia tolerance through upregulated hemoglobin genes, without detectable methylation changes.

Molecular structure of the intact bacterial flagellar basal body

The paper presents the molecular structure of the Salmonella flagellar basal body using cryo-electron microscopy, revealing how 173 protein molecules assemble into a complex spanning two membranes and a cell wall.

Nonameric structures of the cytoplasmic domain of FlhA and SctV in the context of the full-length protein

The paper determines the structure of the nonameric cytoplasmic domains of FlhA and SctV using cryo-EM, revealing a conserved interaction stabilizing the ring assembly.

The Mechanism of Vesicle Solubilization by the Detergent Sodium Dodecyl Sulfate

This study investigates the molecular dynamics of vesicle solubilization by SDS using advanced biophysical methods, revealing biphasic kinetics involving vesicle expansion and rapid lipid loss.

Blood clot fracture properties are dependent on red blood cell and fibrin content

This study experimentally characterizes blood clot fracture properties and develops a predictive model showing that fibrin content significantly affects clot fragmentation risk.

Molecular basis for B. pertussis interference with complement, coagulation, fibrinolytic and contact activation systems: The cryo-EM structure of the Vag8-C1 inhibitor complex

The paper determines the cryo-EM structure of the Vag8-C1-INH complex, revealing how Vag8 disrupts C1-INH function by sequestering its Reactive Centre Loop.

Discovery and Development of Human SARS-CoV-2 Neutralizing Antibodies using an Unbiased Phage Display Library Approach

This study identifies and develops human SARS-CoV-2 neutralizing antibodies using a phage display library, showing their efficacy in vivo against the virus.

Preclinical modeling of surgery and steroid therapy for glioblastoma reveals changes in immunophenotype that are associated with tumor growth and outcome

The paper develops a mouse model to study how surgery and steroids affect immune responses in glioblastoma, finding systemic lymphocyte reduction and correlations with tumor growth and patient outcomes.