Increased deformations are dispensable for cell mechanoresponse in engineered bone analogs mimicking aging bone marrow
A. M. Regner, M. DeLeon, K. D. Gibbons, S. Howard, D. Q. Nesbitt, T. J. Lujan, C. K. Fitzpatrick, M. C. Farach-Carson, D. Wu, G. Uzer
This study shows that increased mechanical strain is not necessary for MSC response to vibration in bone marrow analogs, as lower bone volume fractions still showed reduced collagen and F-actin despite higher strains.
bioRxiv · Sep 24, 2023 · PreprintBioengineering