G. Uzer

Low-intensity vibration does not induce changes in microtubule dynamics in vitro

This study investigates whether low-intensity vibration affects microtubule dynamics in vitro and finds no significant changes compared to controls, unlike Taxol treatment.

Development and Characterization of a low intensity vibrational system for microgravity studies

This paper develops and characterizes a low-intensity vibrational bioreactor for microgravity studies on the International Space Station.

Increased deformations are dispensable for cell mechanoresponse in engineered bone analogs mimicking aging bone marrow

This study shows that increased mechanical strain is not necessary for MSC response to vibration in bone marrow analogs, as lower bone volume fractions still showed reduced collagen and F-actin despite higher strains.

Prrx1-driven LINC complex disruption in vivo reduces osteoid deposition but not bone quality after voluntary wheel running

This study shows that disrupting the LINC complex in bone progenitor cells reduces exercise-induced osteoid deposition but not bone quality in mice.

Osterix-driven LINC complex disruption in vivo diminishes bone microarchitecture in 8-week male mice but not after 6-week voluntary wheel running

This study examines the effect of Osterix-driven LINC complex disruption on bone microarchitecture in mice, finding reduced bone quality at 8 weeks but no significant change after 6 weeks of voluntary running.

Low intensity mechanical signals promote proliferation in a cell-specific manner: Tailoring a non-drug strategy to enhance biomanufacturing yields.

The paper tests low-intensity vibration to enhance cell proliferation in biomanufacturing, showing it can be tailored to different cell types to improve yields.

Data driven and cell specific determination of nuclei-associated actin structure

The paper introduces a machine learning method to quantify and reconstruct nuclei-associated F-actin in mesenchymal stem cells, revealing structural changes upon LINC complex disruption.

Depletion of Sun1/2 induces heterochromatin accrual in mesenchymal stem cells during adipogenesis

The paper compares the effects of Sun1/2 depletion and dnKASH on adipogenesis in MSCs, finding that dnKASH accelerates adipogenesis while Sun1/2 depletion increases heterochromatin on adipogenic genes.

Mechanically induced nuclear shuttling of β-catenin requires co-transfer of actin

This study shows dynamic mechanical strain induces nuclear translocation of β-catenin via actin transport, while static strain promotes YAP1 nuclear entry, highlighting distinct mechanoresponses.

Lamin A/C functions independently from mechanical signaling during adipogenesis

This study shows that Lamin A/C is essential for adipogenesis but not required for mechanical signaling during MSC differentiation.

Modeling stem cell nucleus mechanics using confocal microscopy

The paper develops a computational framework to predict nuclear stiffness from confocal microscopy and AFM data by mapping voxel intensity to mechanical properties.

Low Intensity Vibration Restores Nuclear YAP Levels and Acute YAP Nuclear Shuttling in Mesenchymal Stem Cells Subjected to Simulated Microgravity

This study shows that low intensity vibration (LIV) restores YAP nuclear levels and enhances YAP nuclear entry in mesenchymal stem cells under simulated microgravity.

Isolated Nuclei Stiffen in Response to Low Intensity Vibration

This study shows that isolated nuclei from mesenchymal stem cells become stiffer after low intensity vibration, involving the LINC complex but not LaminA/C or Sun-2.

Mechanical Suppression of Breast Cancer Cell Invasion and Paracrine Signaling Requires Nucleo-Cytoskeletal Connectivity

This study shows that low-intensity vibration reduces breast cancer cell invasion and osteolytic factor secretion by mechanosensory nuclear-cytoskeletal connectivity.