D. Wu

Biodiversity in mountain soils above the treeline

This paper synthesizes research on biodiversity in mountain soils above the treeline, highlighting gaps in geographic and taxonomic coverage and the need for improved data to support conservation efforts.

Targeting IRE1alpha improves insulin sensitivity and thermogenesis and suppresses metabolically active adipose tissue macrophages in male obese mice

This study shows that inhibiting IRE1 improves insulin sensitivity, thermogenesis, and reduces metabolically active adipose tissue macrophages in obese mice.

FLASH radiotherapy using high-energy X-rays: validation of the FLASH effect triggered by a compact single high-energy X-ray source device

This study validates the FLASH effect using a compact high-energy X-ray source in mice, showing protective effects on normal tissues but no significant tumor response differences between FLASH and conventional radiotherapy.

MAPK14/p38α Shapes the Molecular Landscape of Endometrial Cancer and promotes Tumorigenic Characteristics

This study identifies MAPK14/p38α as critical for HGEC spheroid growth, shaping its transcriptomic, proteomic, and metabolomic landscapes and promoting tumorigenic properties.

Structural characterization and AlphaFold modeling of human T cell receptor recognition of NRAS cancer neoantigens

The paper determines crystal structures of a TCR complex with NRAS neoantigens and uses AlphaFold to model these complexes, showing varying success across different implementations.

A Mechanically Resilient Soft Hydrogel Improves Drug Delivery for Treating Post-Traumatic Osteoarthritis in Physically Active Joints

This paper develops a mechanically resilient hydrogel for drug delivery in physically active joints, showing sustained release and reduced cartilage degeneration in a mouse model of post-traumatic osteoarthritis.

FLASH Irradiation Regulates IFN-β induction by mtDNA via Cytochrome c Leakage

This study shows FLASH irradiation increases cytochrome c leakage from mitochondria in normal cells, reducing mtDNA accumulation and IFN-β secretion, while having the opposite effect in cancer cells.

SMARCA2 and SMARCA4 participate in DNA damage repair

This study shows SMARCA2/4 are DNA damage repair factors that relocate to lesions via ATPase activity, independent of gammaH2AX and other sensors, and their loss impairs repair and sensitizes cells to PARP inhibitors.

Efficient differentiation of human retinal pigment epithelium cells from chemically induced pluripotent stem cells

This study develops a chemical method to generate hCiPSCs and demonstrates their efficient differentiation into RPE cells for AMD treatment.

The Kv2.2 channel mediates the inhibition of Prostaglandin E2 on glucose-stimulated insulin secretion in pancreatic β-cells

This study shows PGE2 inhibits glucose-stimulated insulin secretion in β-cells via the EP2/4-Kv2.2 pathway by modulating Kv2.2 channels through PKA.

A longitudinal single-cell and spatial multiomic atlas of pediatric high-grade glioma

This study creates a longitudinal multiomic atlas of pediatric high-grade glioma, revealing distinct tumor cell states and therapeutic targets not seen in adult glioblastoma.

Post-death Vesicles of Senescent Bone Marrow Mesenchymal Stromal Polyploids Promote Macrophage Aging and Breast Cancer

Enhanced microbiota profiling in patients with quiescent Crohn's disease through comparison with paired healthy first-degree relatives using fecal metagenomics and metabolomics

The paper compares microbiota and metabolome profiles of quiescent Crohn's disease patients with their healthy first-degree relatives to identify biomarkers associated with disease relapse.

The interplay between dormant mutated cells and tumor promotion by chronic tissue damage in determining cancer risk.

This study analyzes mouse skin tumors to determine how environmental factors like TPA, obesity, and wounding affect mutational burden and cancer risk, finding that tumor promoters, not mutation number, limit tumor growth.

Epigenetic reprogramming shapes the cellular landscape of schwannoma

This study identifies two molecular groups in schwannomas driven by epigenetic reprogramming and shows ionizing radiation can reprogram neural crest to immune-enriched schwannomas.

Efficacy of Drpitor1a, a Dynamin-Related Protein 1 inhibitor, in Pulmonary Arterial Hypertension

This study evaluates Drpitor1a, a Drp1 inhibitor, showing efficacy in reducing PAH in female rats and human PASMCs without toxicity.

Unraveling the Impact of W215A/E217A Mutations on Thrombin Dynamics and Thrombomodulin Binding through Molecular Dynamics Simulations

This study uses molecular dynamics simulations to analyze how W215A/E217A mutations affect thrombin's substrate specificity and TM binding, revealing structural changes and identifying ARG125 as a key residue.

SntB triggers the antioxidant pathways to regulate development and aflatoxin biosynthesis in Aspergillus flavus

This study identifies SntB as a regulator of growth, development, and aflatoxin biosynthesis in Aspergillus flavus by modulating antioxidant pathways and gene expression.

Site Effects in Multisite Fetal Brain MRI: Morphological Insights into Early Brain Development

This study identifies key MRI acquisition factors affecting fetal brain morphology and shows that ComBat-GAM harmonization effectively reduces site effects while preserving developmental patterns.

Assembly reactions of SARS-CoV-2 nucleocapsid protein with nucleic acid

This study investigates the assembly of SARS-CoV-2 nucleocapsid protein with nucleic acids using biophysical techniques and mutant proteins, revealing key interaction motifs and stabilization mechanisms.

Modulation of Biophysical Properties of Nucleocapsid Protein in the Mutant Spectrum of SARS-CoV-2

The paper examines how mutations in SARS-CoV-2 nucleocapsid protein's intrinsically disordered regions affect its biophysical properties across different variants.

Development and Characterization of a low intensity vibrational system for microgravity studies

This paper develops and characterizes a low-intensity vibrational bioreactor for microgravity studies on the International Space Station.

The DNA Damage Response (DDR) landscape of endometrial cancer defines discrete disease subtypes and reveals therapeutic opportunities.

This study characterizes DDR and CTA transcriptional landscapes in endometrial cancer subtypes, identifies aggressive subtypes, and reveals therapeutic vulnerabilities.

Trans-Lesion Synthesis and Mismatch Repair Pathway Crosstalk Defines Chemoresistance and Hypermutation Mechanisms in Glioblastoma

This study identifies RAD18's role in TMZ resistance and hypermutation in GBM by linking it to TLS and MMR pathways through CRISPR screening and mutation analysis.

Regulated Cleavage and Relocation of FERONIA Control Immunity in Arabidopsis Roots

Bacteria induce FER cleavage via At2-MMP to trigger localized immunity in Arabidopsis root transition/elongation zones.

Increased deformations are dispensable for cell mechanoresponse in engineered bone analogs mimicking aging bone marrow

This study shows that increased mechanical strain is not necessary for MSC response to vibration in bone marrow analogs, as lower bone volume fractions still showed reduced collagen and F-actin despite higher strains.

Trem2 Agonist Reprograms Foamy Macrophages to Promote Atherosclerotic Plaque Stability

This study shows that a Trem2 agonist increases plaque macrophage survival and proliferation while improving plaque stability by enhancing collagen deposition and reducing necrotic core size.

Structural and mechanistic insights into human choline and ethanolamine transport

This study identifies FLVCR1 and FLVCR2 as choline and ethanolamine transporters, revealing their structural dynamics and substrate selectivity mechanisms.

Metagenomic analysis of individual mosquitos reveals the ecology of insect viruses

The paper analyzes the virome of 2,438 individual mosquitoes across China to reveal viral diversity, geographic hotspots, and the impact of host phylogeny on viral composition.

In vivo Mapping of Cellular Resolution Neuropathology in Brain Ischemia by Diffusion MRI

This paper introduces tDKI to map cellular pathology in brain ischemia, showing it detects changes in cell morphology and membrane permeability in vivo.