A Human-Immune-System (HIS) humanized mouse model (DRAGA: HLA-A2. HLA-DR4. Rag1 KO.IL-2Rγc KO. NOD) for COVID-19
T.-D. Brumeanu, P. Vir, A. F. Karim, S. Kar, D. Benetiene, M. Lok, J. Greenhouse, T. Putmon-Taylor, C. Kitajewski, K. K. Chung, K. P. Pratt, S. A. Casares
The paper introduces a humanized mouse model for studying SARS-CoV-2 infection and develops its use for vaccine and therapeutic testing.
bioRxiv · Aug 19, 2020 · PreprintImmunology