S. Kar

Endothelial gain of PIEZO/TRPV mechanosensors drives cavernous malformations

This study identifies PIEZO1, TRPV2, and TRPV4 as mechanosensors overexpressed in CCM lesions, showing their role in driving disease through altered adhesion and matrix degradation.

Naphthalimide-based, Single-Chromophore, Ratiometric Fluorescent Sensor for Tracking Intracellular pH

The paper introduces a novel ratiometric fluorescent sensor, TRapH, for tracking intracellular pH in living cells and demonstrates its use in monitoring pH dynamics induced by a synthetic H+-transporter.

Immunogenicity and efficacy of a subcutaneously administered, adjuvanted vaccine containing modified S1 spike protein of SARS-CoV-2 variant C.1.2

This paper evaluates a subcutaneously administered vaccine targeting the S1 spike protein of SARS-CoV-2 variant C.1.2, showing robust IgG responses and protection against Omicron BA.1 challenge in hamsters.

Strong immunogenicity & protection in mice with PlaCCine: A COVID-19 DNA vaccine formulated with a functional polymer

This study evaluates a DNA vaccine, PlaCCine, showing strong immunogenicity and protection in mice against SARS-CoV-2 variants.

Disentangling the cascading effects of Grapevine Red Blotch Virus infection on vine physiology

This study investigates how Grapevine Red Blotch Virus affects carbon assimilation and ripening in Vitis vinifera by measuring physiological changes in infected and healthy vines.

Spatial structure imposes sex-specific costs but does not reduce interlocus sexual conflict

The paper tests how spatial structure affects interlocus sexual conflict in Drosophila melanogaster, finding sex-specific survival costs but no strong evidence of spatial structuring modulating conflict intensity.

Transpiration and water use efficiency of sorghum canopies have a large genetic variability and are positively related under naturally high evaporative demand.

The paper examines genetic variability in sorghum transpiration and water use efficiency under varying evaporative demand, finding a positive correlation between transpiration and WUE in high evaporative demand conditions.

Association of seminal polyaromatic hydrocarbons exposome with idiopathic male factor infertility: A proteomic insight into sperm function

This study links seminal polyaromatic hydrocarbons (PAHs) exposure to idiopathic male infertility through proteomic analysis, identifying key proteins and pathways involved in oxidative stress and mitochondrial dysfunction.

Synthetic Multiantigen MVA Vaccine COH04S1 Protects Against SARS-CoV-2 in Syrian Hamsters and Non-Human Primates

This paper shows that the synthetic multiantigen MVA vaccine COH04S1 protects against SARS-CoV-2 in Syrian hamsters and non-human primates through various vaccination routes and dose regimens.

Reduced Pathogenicity of the SARS-CoV-2 Omicron Variant in Hamsters

This study shows the SARS-CoV-2 Omicron variant causes less weight loss in hamsters than previous variants, suggesting reduced lower respiratory tract disease severity.

Protection from SARS-CoV-2 Delta one year after mRNA-1273 vaccination in nonhuman primates is coincident with an anamnestic antibody response in the lower airway

This study shows that mRNA-1273 vaccine protection against SARS-CoV-2 Delta in nonhuman primates persists for one year but is delayed and relies on anamnestic antibody responses in the lower airway.

Redox state and cellular uptake of copper is regulated by the N-terminus of human Copper Transporter-1

The paper shows that the N-terminus of hCTR1 regulates copper uptake by coordinating Cu(I) and facilitating its reduction from Cu(II).

One mucosal administration of a live attenuated recombinant COVID-19 vaccine protects non-human primates from SARS-CoV-2

This study shows that a single mucosal dose of the live attenuated RSV-based vaccine MV-014-212 protects non-human primates from SARS-CoV-2 infection by reducing viral shedding and inducing neutralizing antibodies.

A SARS-CoV-2 spike ferritin nanoparticle vaccine protects against heterologous challenge with B.1.1.7 and B.1.351 virus variants in Syrian golden hamsters

This study evaluates a SARS-CoV-2 spike ferritin nanoparticle vaccine's effectiveness against B.1.1.7 and B.1.351 variants in hamsters, showing protection against disease and viral replication.

Evaluation of mRNA-1273 against SARS-CoV-2 B.1.351 Infection in Nonhuman Primates

This study evaluates mRNA-1273 vaccine efficacy against SARS-CoV-2 B.1.351 in nonhuman primates, finding that two doses significantly reduce viral replication in the airways.

Design, immunogenicity and efficacy of a Pan-SARS-CoV-2 synthetic DNA vaccine

This study designs and tests a DNA vaccine, INO-4802, which induces broad immunity against multiple SARS-CoV-2 variants in animal models.

Immune Correlates of Protection by mRNA-1273 Immunization against SARS-CoV-2 Infection in Nonhuman Primates

This study shows that mRNA-1273 vaccine-induced antibody responses correlate with protection against SARS-CoV-2 infection in nonhuman primates.

Rapalogs downmodulate intrinsic immunity and promote cell entry of SARS-CoV-2

This study shows rapalogs like rapamycin increase SARS-CoV-2 infection by reducing antiviral proteins through microautophagy, while ridaforolimus has less effect.

One dose of COVID-19 nanoparticle vaccine REVC-128 provides protection against SARS-CoV-2 challenge at two weeks post immunization

Copper dependent ERK1/2 phosphorylation is essential for the viability of neurons and not glia

This study shows that copper-dependent ERK1/2 phosphorylation is essential for neuronal viability but not glial cells during differentiation.

Neural epidermal growth factor-like 1 protein variant increases survival and modulates the inflammatory and immune responses in human ACE-2 transgenic mice infected with SARS-CoV-2

This study tests a recombinant NELL1 protein variant in a SARS-CoV-2 mouse model, showing improved survival and modulated immune responses.

Suppression of miR-155 attenuates lung cytokine storm induced by SARS-CoV-2 infection in human ACE2-transgenic mice

This study shows that suppressing miR-155 reduces lung inflammation and improves survival in SARS-CoV-2-infected human ACE2-transgenic mice.

A Human-Immune-System (HIS) humanized mouse model (DRAGA: HLA-A2. HLA-DR4. Rag1 KO.IL-2Rγc KO. NOD) for COVID-19

The paper introduces a humanized mouse model for studying SARS-CoV-2 infection and develops its use for vaccine and therapeutic testing.

Transcriptomic expression patterns of two contrasting lowland rice varieties reveal high iron stress tolerance

The paper compares transcriptomic responses of two lowland rice varieties, Lachit and Hacha, under iron excess stress, identifying gene expression patterns linked to iron tolerance.

Germline and somatic genetic variants in the p53 pathway interact to affect cancer risk, progression and drug response

The paper investigates interactions between germline and somatic variants in the p53 pathway to show their combined effects on cancer risk, progression, and treatment response.

Anemia Diagnosis on a Simple Paper-based Assay

This paper develops a low-cost, paper-based microfluidic device for anemia detection with high correlation and accuracy compared to standard tests.