Allergen-induced dendritic cell migration is controlled through Substance P release by sensory neurons
P. A. Aderhold, Z. N. A. Dewan, C. Perner, C. H. Flayer, X. Zhu, T. Voisin, R. B. Camire, I. Chiu, O. A. Chow, C. L. Sokol
This study shows allergen-activated sensory neurons release Substance P, which activates CD301b+ dendritic cells to migrate to lymph nodes and initiate Th2 responses.
bioRxiv · Jun 5, 2020 · PreprintImmunology