X. Zhu

The discovery of antimicrobial peptides from the gut microbiome of cockroach Blattella germanica using deep learning pipeline

The paper develops a deep learning pipeline to identify antimicrobial peptides from the gut microbiome of Blattella germanica, finding two AMPs with low toxicity and antimicrobial activity.

Dynamic Regulation of Innate Lymphoid Cell Development During Ontogeny

This study investigates the developmental changes in innate lymphoid cell (ILC) subsets using scRNA-seq and differentiation assays, revealing distinct regulatory programs in fetal and adult stages.

Cross-species genomic survey reveals a single origin of the soft-shelled turtles

This study reveals that soft-shelled turtles have a single origin of their ZW-type sex chromosomes, coinciding with the Paleocene-Eocene thermal maximum.

Blocker-SELEX: A Structure-guided Strategy for Developing Inhibitory Aptamers Disrupting Undruggable Transcription Factor Interactions

This paper introduces Blocker-SELEX, a structure-guided method to design inhibitory aptamers that disrupt transcription factor interactions, demonstrating efficacy against SCAF4/SCAF8-RNAP2 and WDR5-MYC complexes.

The ICF2 gene Zbtb24 specifically regulates the differentiation of B1 cells via promoting heme synthesis

This study shows that Zbtb24 regulates B1 cell differentiation via heme synthesis, leading to impaired antibody production in T-cell independent responses.

A Day in the Life of Arabidopsis: 24-Hour Time-lapse Single-nucleus Transcriptomics Reveal Cell-type specific Circadian Rhythms

This study uses snRNA-seq to analyze circadian rhythms in Arabidopsis over 24 hours, revealing cell-type specific gene expression patterns and identifying key circadian regulators.

Inhibition of KLK8 promotes pulmonary endothelial repair by restoring VE-cadherin/Akt/FOXM1 pathway

This study shows that inhibiting KLK8 restores the VE-cadherin/Akt/FOXM1 pathway, promoting endothelial repair and reducing sepsis-induced lung injury and mortality.

Structural and mechanistic insights into disease-associated endolysosomal exonucleases PLD3 and PLD4

This study reports the structures and mechanistic insights of PLD3 and PLD4, revealing their exonuclease activity, phosphatase function, and disease relevance.

Captivity affects mitochondrial aerobic respiration and carotenoid metabolism in the house finch (Haemorhous mexicanus)

This study shows that captivity in cages reduces red carotenoid circulation and increases mitochondrial respiratory rates in house finches, supporting a link between carotenoid metabolism and mitochondrial function.

Distinct Roles of Kif6 and Kif9 in Mammalian Ciliary Trafficking and Motility

This study identifies distinct roles of Kif6 and Kif9 in mammalian ciliary trafficking and motility, showing Kif6 is a motile cilia-specific IFT motor while Kif9 regulates the central apparatus.

Pulmonary Ventilation Analysis Using 1H Ultra-Short Echo Time (UTE) Lung MRI: A Reproducibility Study

This study evaluates methods for quantifying pulmonary ventilation using 1H UTE MRI, finding that cyclic b-spline registration and specific ventilation provide the most reproducible results.

NeuroMotion: Open-source Simulator with Neuromechanical and Deep Network Models to Generate Surface EMG signals during Voluntary Movement

NeuroMotion generates synthetic EMG signals during voluntary movements by integrating musculoskeletal models, neural networks, and motor unit models, enabling analysis of neuromechanical interactions.

Inhibition of SARS-CoV-2 Infection in Human Airway Epithelium with a Xeno-Nucleic Acid Aptamer

This study shows that FANA-R8-9 aptamer inhibits SARS-CoV-2 infection in human airway epithelium models and is stable and non-toxic.

Enhancing plant photosynthesis through activating cells deficient in photosynthetic apparatus

This study enhances plant photosynthesis by activating CGA1 in vascular bundle and bundle sheath cells, leading to increased chloroplasts, RuBisCO, and biomass with a 20% increase.

Dairy practices select for thermostable endolysins in phages

The paper shows that dairy practices have selected for thermostable endolysins in phages infecting Streptococcus thermophilus, reducing endolysin diversity.

Progressive community, biogeochemical and evolutionary remodeling of the soil microbiome underpins long-term desert ecosystem restoration

This study examines the long-term microbial changes in desert soil during ecological restoration, finding shifts in community structure, functional diversity, and biogeochemical cycles over 17 years.

The crystal and cryo-EM structures of PLCγ2 reveal dynamic inter-domain recognitions in autoinhibition

The paper determines crystal and cryo-EM structures of PLCγ2 in autoinhibited states and bound to FGFR1 kinase domain, revealing dynamic inter-domain interactions in autoinhibition.

Multiscale effects of perturbed translation dynamics inform antimalarial design

The paper determines in situ structures of Pf80S ribosomes in Plasmodium falciparum-infected erythrocytes, identifies a bifurcation in translation elongation, and links perturbations to inhibitor effects on ribosome interactions.

Massively Concurrent Sub-Cellular Traction Force Videography enabled by Single-Pixel Optical Tracers (SPOTs)

The paper introduces a high-speed, large-field-of-view platform for measuring sub-cellular traction forces in over 10,000 cells at 83 frames per second.

Host-microbiota interactions contributing to the heterogeneous tumor microenvironment in colorectal cancer

The paper identifies host-microbiota interactions in colorectal cancer subtypes, revealing distinct gene-microbe associations that contribute to tumor microenvironment heterogeneity.

A microfluidic strategy to capture antigen-specific high affinity B cells

This paper introduces a microfluidic method to assess B cell affinity to antigens under force, showing it can enrich high-affinity B cells and correlate with solution-based antibody affinity.

A framework for Frizzled-G protein coupling and implications to the Wnt-PCP signaling pathways

This study presents cryo-EM structures of FZD6, FZD3, and FZD1 in active and inactive states, revealing a shared activation framework and potential crosstalk between G-protein binding and Wnt-PCP signaling.

High-resolution structure of mouse radial spoke and its in-situ structure in ependymal cilia revealed by cryo-EM and cryo-ET

The paper presents high-resolution cryo-EM structures of mouse radial spokes and cryo-ET maps of ependymal cilia, revealing structural features and mutations linked to ciliary disorders.

HMGB1 acts as an agent of host defense at the gut mucosal barrier

This study identifies HMGB1 as a host defense molecule in the gut mucosal barrier that targets bacterial adhesins to prevent microbial invasion and adhesion.

Co-engagement of TIGIT+ immune cells to PD-L1+ tumours by a bispecific antibody potentiates T-cell response and tumour control

This paper shows that a bispecific antibody targeting PD-L1 and TIGIT enhances T-cell response and tumor control compared to using the individual antibodies.

Broadly neutralizing antibodies targeting a conserved silent face of spike RBD resist extreme SARS-CoV-2 antigenic drift

The paper identifies broadly neutralizing antibodies against SARS-CoV-2 that target conserved regions on the spike RBD, showing resistance to antigenic drift and suggesting potential vaccine targets.

Overexpression of the violaxanthin de-epoxidase confers faster NPQ and photosynthesis induction in rice

This study shows overexpressing VDE in rice speeds up NPQ and photosynthesis induction, reduces photoinhibition, and increases biomass by 11-16% in field conditions.

Two haplotype-resolved genomes of highly heterozygous AAB allotriploid bananas provide insights into subgenome asymmetric evolution and banana wilt control

This study presents haplotype-resolved genomes of triploid bananas, revealing subgenome asymmetric evolution and resistance mechanisms against banana wilt.

Development of membrane-like pre-stem cells after released from tube-shaped niches

The paper identifies two membrane-like pre-stem progenitors that develop into c-kit-positive stem cell progenitors and multi-nucleated cells, challenging existing concepts of stem cell self-renewal and lineage origins.

A proximity-dependent biotinylation map of cytosol-facing organelle outer membrane proteome in living Arabidopsis cells

The paper develops an OM proximity labeling system to map the proteome of cytosol-facing outer membranes in Arabidopsis cells and identifies potential receptors for protein translocation and organelle communication.