HIF-1 inactivation empowers HIF-2 to drive hypoxia adaptation in aggressive forms of medulloblastoma
J. Contenti, Y. Guo, M. Larcher, L. Mirabal-Ortega, M. ROULEAU, M. Irondelle, V. Tiroille, A. Mazzu, V. Duranton-Tanneur, F. Pedeutour, I. Ben-Sahra, C. Lago, G. Leva, L. Tiberi, G. Robert, , N. M. Mazure
This study shows that Group 3 medulloblastoma cells rely on HIF-2 instead of HIF-1 for hypoxia adaptation, and inhibiting HIF-2 with metformin kills these cells more effectively than non-Group 3 cells.
bioRxiv · Oct 17, 2023Cancer Biology