Author

M. Larcher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

C. Pouponnot· 2 shared A. Delaidelli· 1 shared A. Mazzu· 1 shared B. Rotblat· 1 shared C. Dunham· 1 shared C. Lago· 1 shared D. Picard· 1 shared F. Bost· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

C. Pouponnot

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2 papers

Recent·Most cited

The EIF4EBP1 gene encoding 4EBP1 is transcriptionally upregulated by MYC and linked to shorter survival in medulloblastoma

L. Hruby, K. Scharov, A. Delaidelli, D. Picard, C. Dunham, O. Lewandowska, T. Reiff, M. Larcher, C. Pouponnot, P. H. Sorensen, B. Rotblat, G. Reifenberger, M. Remke, G. Leprivier

This study shows that EIF4EBP1 is upregulated by MYC in medulloblastoma and linked to poorer patient survival.

bioRxiv · Mar 6, 2024 · PreprintCancer Biology

HIF-1 inactivation empowers HIF-2 to drive hypoxia adaptation in aggressive forms of medulloblastoma

J. Contenti, Y. Guo, M. Larcher, L. Mirabal-Ortega, M. ROULEAU, M. Irondelle, V. Tiroille, A. Mazzu, V. Duranton-Tanneur, F. Pedeutour, I. Ben-Sahra, C. Lago, G. Leva, L. Tiberi, G. Robert, , N. M. Mazure

This study shows that Group 3 medulloblastoma cells rely on HIF-2 instead of HIF-1 for hypoxia adaptation, and inhibiting HIF-2 with metformin kills these cells more effectively than non-Group 3 cells.

bioRxiv · Oct 17, 2023Cancer Biology