Y. Guo

Follow-up availability and the robustness of immune transcriptomic recovery after myocardial infarction

The paper assesses the robustness of immune transcriptomic recovery after myocardial infarction by evaluating how missing data and assay availability affect inflammatory-response scores over time.

YAP/TAZ enhance P-body formation to promote tumorigenesis

This study shows YAP/TAZ promote P-body formation in cancer cells, enhancing tumorigenesis, and suggests targeting P-bodies or PNRC1 could be therapeutic.

Reprograming gene expression in "hibernating" C. elegans involves the IRE-1/XBP-1 pathway

This study identifies the IRE-1/XBP-1 pathway as critical for cold-induced gene regulation in C. elegans, linking it to survival during cold stress.

Two mechanisms of photoenergy regulation revealed by kinetic behaviors of chlorophyll fluorescence during light adaptation

The paper identifies two mechanisms of photoenergy regulation in PSII using chlorophyll fluorescence kinetics: one involving PsbS-mediated NPQ and another involving zeaxanthin and lutein disrupting energy transfer to P680.

Platelet integrin αIIbβ3 plays a key role in venous thrombogenesis in a mouse model

This paper shows that m-tirofiban, a non-partial agonist of IIbβ3, effectively inhibits venous thrombosis without increasing bleeding in a mouse model.

Clathrin-associated carriers enable recycling through a kiss-and-run mechanism

The paper identifies a novel endocytic recycling mechanism called CARP, which involves clathrin-associated carriers undergoing partial membrane fusion and release.

An emerging PB2-627 polymorphism increases the pandemic potential of avian influenza virus by breaking through ANP32 host restriction in mammalian and avian hosts

This paper identifies a PB2-627V mutation in avian influenza viruses that enhances pandemic potential by overcoming host restriction through ANP32A proteins in both avian and mammalian hosts.

A Drug-Elicitable Alternative-Splicing Module (DreAM) for Tunable AAV Expression and Controlled Myocardial Regeneration

Nuclear receptor E75/NR1D2 drives tumor malignant transformation by integrating Hippo and Notch pathways

The paper shows that E75/NR1D2 integrates Hippo and Notch pathways to drive tumor malignancy in response to hormone inhibition.

Macrophages facilitate interclonal cooperation-induced tumor heterogeneity and malignancy by activating the innate immune signaling

This study shows that macrophages in Drosophila tumors promote heterogeneity and malignancy by activating innate immune signaling through the Toll pathway.

Cmai: Predicting Antigen-Antibody Interactions from Massive Sequencing Data

Cmai predicts antigen-antibody interactions from high-throughput BCR sequencing data, revealing immune responses to tumor antigens and ICI treatment outcomes.

scCancerExplorer: a comprehensive database for interactively exploring single-cell multi-omics data of human pan-cancer

scCancerExplorer provides an interactive database for exploring single-cell multi-omics data across 50 cancer types, integrating genomic, epigenomic, and transcriptomic data.

Spatiotemporal analysis of F-actin polymerization with micropillar arrays reveals synchronization between adhesion sites

This study uses micropillar arrays to analyze F-actin polymerization dynamics in mouse embryonic fibroblasts, revealing synchronized adhesion site communication through spatiotemporal analysis.

HIV-1 neutralizing antibodies in SHIV-infected macaques recapitulate structurally divergent modes of human V2 apex recognition with a single D gene

This study isolates and characterizes V2 apex-directed neutralizing antibodies from SHIV-infected macaques, revealing structural and genetic features that enable broad neutralization.

Myocardial infarction creates a critical time window for AAV gene therapy

This paper shows that myocardial infarction creates a time window where AAV gene therapy is more effective in mice, improving gene expression and therapeutic outcomes when administered three days post-infarction.

Recurrent SARS-CoV-2 spike mutations confer growth advantages to select JN.1 sublineages

This study examines how recurrent spike mutations in SARS-CoV-2 JN.1 sublineages affect immune evasion, ACE2 affinity, and infectivity, identifying growth advantages in specific sublineages.

Impact of variants and vaccination on nasal immunity across three waves of SARS-CoV-2

This study examines how SARS-CoV-2 variants and vaccination affect nasal immunity across three waves, identifying changes in cellular states and immune responses.

Pharmacodynamic modeling of colistin and imipenem against in vitro Pseudomonas aeruginosa biofilms

This study develops a PK-PD model for imipenem and colistin against Pseudomonas aeruginosa biofilms to optimize clinical dosing schedules.

Asymmetric binding of coactivator SRC1 to FXR-RXR and allosteric communication within the complex

This study reveals the asymmetric binding of SRC1 to FXR-RXR and the allosteric communication within the complex, providing a structural model for understanding FXR function and its disease implications.

Positive Selection on Rare Variants Underlying the Cold Adaptation of Wild Boar

This study identifies rare variants under positive selection in wild boar linked to cold adaptation, showing convergent molecular evolution with humans.

The mating ritual of a rainforest tinamou, Tinamus major

The paper observes and analyzes the mating behavior of Great Tinamous in their natural habitat, revealing that the female performs most courtship displays and songs, challenging previous assumptions about male courtship roles.

14-3-3 binding motif phosphorylation disrupts Hdac4 organized condensates to stimulate cardiacreprogramming

This study identifies a phosphorylation code in 14-3-3 binding motifs that stimulates induced cardiomyocyte formation by disrupting Hdac4 condensates.

The focal adhesion protein talin is a mechanically-gated A-kinase anchoring protein (AKAP)

This study identifies talin1 as a mechanically-gated AKAP that binds PKA through a force-dependent interaction in focal adhesions.

A multi-modal image fusion workflow incorporating MALDI imaging mass spectrometry and microscopy for the study of small pharmaceutical compounds

This paper presents a multi-modal image fusion workflow combining MALDI imaging mass spectrometry with microscopy to improve spatial resolution and co-registration of pharmaceutical compound and receptor data.

SARS-CoV-2 Omicron BA.2.87.1 Exhibits Higher Susceptibility to Serum Neutralization Than EG.5.1 and JN.1

This study compares the antibody evasion, ACE2 binding, and infectivity of SARS-CoV-2 BA.2.87.1 with EG.5.1 and JN.1, finding BA.2.87.1 has lower immune evasion and reduced infectivity.

Efficient cloning of genes for wheat yield component traits from QTLs via sequencing of the RIL population

This study develops a method to clone genes for wheat yield traits by sequencing RIL populations, identifying and validating 11 candidate genes from 77 QTLs.

Robust SARS-CoV-2 Neutralizing Antibodies Sustained through Three Months Post XBB.1.5 mRNA Vaccine Booster

This study shows that neutralizing antibodies against SARS-CoV-2 variants remain stable for three months after an XBB.1.5 mRNA vaccine booster.

Adaptive diversification through structural variation in barley

This study presents a barley pangenome revealing structural variation linked to traits like disease resistance and plant architecture, highlighting its role in adaptive evolution.

Variant Surface Protein GP60 Contributes to Host Infectivity of Cryptosporidium parvum

The paper investigates the role of GP60 in Cryptosporidium parvum infectivity, finding that while GP60 is not essential, its cleavage products affect parasite growth and infection severity.

TPPB modulates PKC activity to attenuate neuroinflammation and ameliorate experimental multiple sclerosis

This study shows TPPB, a new PKC modulator, reduces neuroinflammation and promotes CNS repair in experimental MS by targeting innate immune cells.