HIF-1alpha is Required to Differentiate the Neonatal Macrophage Secretome from Adults
A. Becker, M. Filipp, C. Lantz, K. Glinton, E. B. Thorp
The paper identifies age-specific secretome differences in macrophages under hypoxia and LPS, showing neonatal macrophages have anti-inflammatory, regenerative properties dependent on HIF-1, while adult macrophages show pro-inflammatory, glycolytic responses.
bioRxiv · Apr 24, 2024 · PreprintImmunology