A. Becker

Extracellular vesicle mobility in collagen I hydrogels is influenced by RGD-binding integrins

This study investigates how extracellular vesicle mobility in collagen I hydrogels is influenced by RGD-binding integrins, showing that integrin inhibition increases EV mobility.

HIF-1alpha is Required to Differentiate the Neonatal Macrophage Secretome from Adults

The paper identifies age-specific secretome differences in macrophages under hypoxia and LPS, showing neonatal macrophages have anti-inflammatory, regenerative properties dependent on HIF-1, while adult macrophages show pro-inflammatory, glycolytic responses.

Mesoscale DNA Features Impact APOBEC3A and APOBEC3B Deaminase Activity and Shape Tumor Mutational Landscapes

This study identifies how mesoscale DNA features influence APOBEC3A and APOBEC3B deaminase activity and their impact on tumor mutational landscapes.

Alzheimer's disease linked Aβ42 exerts product feedback inhibition on γ-secretase impairing downstream cell signaling

This study shows that human Aβ42 inhibits γ-secretase, leading to substrate accumulation and neuronal dysfunction, suggesting a feedback mechanism in Alzheimer's disease.

DNA replication is not a limiting factor for the rapid growth of Vibrio natriegens

The paper investigates whether DNA replication limits the rapid growth of Vibrio natriegens by creating a strain with a single origin of replication, finding no significant change in growth rate.

NAD+ metabolism is a key modulator of bacterial respiratory epithelial infections

The paper investigates how NAD+ metabolism affects bacterial respiratory infections, finding that modulating NAD+ levels impacts both host and bacterial outcomes.

Structural basis of bifunctionality of Sinorhizobium meliloti Clr, a cAMP and cGMP receptor protein

This paper reports the structural analysis of Sinorhizobium meliloti Clr, showing it activates transcription in response to both cAMP and cGMP through distinct conformational shifts.

Identification of Ensifer meliloti genes required for survival during peat-based bioinoculant maturation by STM-seq

This paper uses STM-seq to identify Ensifer meliloti genes critical for survival during peat-based inoculant maturation, revealing key factors affecting rhizobial viability and competitiveness.

Engineering a Sinorhizobium meliloti chassis with monopartite, single replicon genome configuration

The paper simplifies the multipartite genome of Sinorhizobium meliloti by creating bi- and monopartite configurations, showing that monopartite genomes can be functional but have growth and localization issues.

GBS and a newly developed mRNA-GBS approach to link population genetic and transcriptome analyses reveal pattern differences between sites and treatments in red clover (Trifolium pratense L.)

The paper develops and evaluates an mRNA-GBS method to analyze genetic and transcriptome variation in red clover, finding it comparable to GBS but with challenges in linking transcriptome data to prior studies.

The CRP-like transcriptional regulator MrpC curbs c-di-GMP and 3,3 cGAMP nucleotide levels during development in Myxococcus xanthus

This paper identifies MrpC as a key regulator of c-di-GMP and 3,3 cGAMP levels during development in Myxococcus xanthus by directly controlling the expression of dmxB and pmxA.

Autoantibodies against Progranulin and IL-1 receptor antagonist due to immunogenic posttranslational isoforms contribute to hyperinflammation in critically ill COVID-19

This study identifies autoantibodies against PGRN and IL-1-Ra in critical COVID-19 patients, linked to hyperphosphorylated isoforms and increased inflammation.

Unipolar peptidoglycan synthesis in the Rhizobiales requires an essential class A penicillin-binding protein

The paper investigates polar peptidoglycan synthesis in Rhizobiales using fluorescent probes and finds that a single class A penicillin-binding protein is essential for this process.

Cryo-EM structural studies of the agonist complexed human TRPV4 ion-channel reveals novel structural rearrangements resulting in an open-conformation

This paper reports the cryo-EM structure of hTRPV4 in an open conformation induced by 4-PDD agonist, revealing molecular mechanisms of activation and providing a template for inhibitor design.

High-resolution temporal transcript profiling during Arabidopsis thaliana gynoecium morphogenesis uncovers the chronology of gene regulatory network activity and reveals novel developmental regulators

This study uses high-resolution transcript profiling to uncover gene regulatory networks and novel regulators during Arabidopsis gynoecium development.

Deep Learning for Virtual Screening: Five Reasons to Use ROC Cost Functions

This paper argues for using ROC cost functions in deep learning for virtual screening to address class imbalance and decision threshold challenges, showing improved performance on drug discovery datasets.

Tol-Pal system and Rgs proteins interact to promote unipolar growth and cell division in Sinorhizobium meliloti

This study identifies and characterizes Rgs proteins and the Tol-Pal system in S. meliloti, showing their roles in unipolar growth and cell division.

Transcriptional changes suggest a major involvement of Gibberellins in Trifolium pratense regrowth after mowing

The paper identifies gibberellin-related genes involved in red clover regrowth after mowing using transcriptomics and shows exogenous GA application rescues regrowth morphology.

Histone methyltransferase MMSET/NSD2 is essential for generation of B1 cell compartment in mice

This study identifies MMSET/NSD2 as essential for B1 cell development in mice, showing its role in histone methylation and B cell lineage specification.

Can a red wood-ant nest be a trap for fault-related CH4 micro-seepage? A case study from continuous short-term in-situ sampling

The paper investigates methane sources in a red wood-ant nest, finding microbial and fault-related emissions, with a novel signature indicating fault-related CH4 trapping.

A dead gene walking: convergent degeneration of a clade of MADS-box genes in Brassicaceae

The paper investigates gene death in Brassicaceae, showing that GOA-like genes undergo convergent degeneration while their paralogs, ABS-like genes, remain conserved.