Human Abdominal Subcutaneous-Derived Active Beige Adipocytes Carrying FTO rs1421085 Obesity-Risk Alleles Exert Lower Thermogenic Capacity
A. Vamos, R. Arianti, B. A. Vinnai, R. Alrifai, A. Shaw, S. Poliska, A. Guba, E. Csosz, I. Csomos, G. Mocsar, C. Lanyi, Z. Balajthy, L. Fesüs, E. Kristof
The paper investigates how FTO rs1421085 obesity-risk alleles affect thermogenic capacity in human beige adipocytes, finding reduced thermogenesis and gene expression in CC carriers.
bioRxiv · Jan 30, 2023Cell Biology