A. Shaw

Dectin-1 Stimulation Promotes a Distinct Inflammatory Signature in the Setting of HIV-infection and Aging

This study shows that HIV-positive older adults have a unique inflammatory response to Dectin-1 stimulation, marked by increased cytokines and immune activation.

Nanopore molecular trajectories of a eukaryotic reverse transcriptase reveal a long-range RNA structure sensing mechanism

The paper uses nanopore sequencing to study the single-nucleotide kinetics of a reverse transcriptase, revealing its ability to sense and destabilize RNA structures during cDNA synthesis.

Regulation of Human PINK1 ubiquitin kinase by Serine167, Serine228 and Cysteine412 phosphorylation

This study identifies phosphorylation sites in hPINK1 that regulate its activation and ubiquitin interaction, revealing a novel inhibitory mechanism involving pCys412.

Human Abdominal Subcutaneous-Derived Active Beige Adipocytes Carrying FTO rs1421085 Obesity-Risk Alleles Exert Lower Thermogenic Capacity

The paper investigates how FTO rs1421085 obesity-risk alleles affect thermogenic capacity in human beige adipocytes, finding reduced thermogenesis and gene expression in CC carriers.

The City Nature Challenge - A global citizen science phenomenon contributing to biodiversity knowledge and informing local government practices

The paper evaluates the City Nature Challenge's contribution to biodiversity knowledge and local government practices through a case study and framework development.

Timing and magnitude of the type-I interferon response are determinants of disease tolerance in arbovirus infection

This study shows that the timing and magnitude of the type-I interferon response determine disease tolerance in bluetongue virus infection between sheep and cattle.

Mitophagy mediates beige to white transition of human primary subcutaneous adipocytes ex vivo

This study shows that mitophagy mediates the beige to white transition in human adipocytes, with implications for thermogenesis and energy expenditure.

No evidence of fetal defects or anti-syncytin-1 antibody induction following COVID-19 mRNA vaccination

This study investigates whether COVID-19 mRNA vaccination affects pregnancy outcomes or induces anti-syncytin-1 antibodies, finding no evidence of fetal defects or increased antibody levels.

Rigid DNA nanotube tethers suppress high frequency noise in dual-trap optical tweezers systems

This study evaluates how rigid DNA nanotube tethers affect noise in dual-trap optical tweezers systems, finding they suppress high-frequency noise but not low-frequency noise.

BMP7 increases UCP1-dependent and independent thermogenesis with a unique gene expression program in human neck area derived adipocytes

This study shows BMP7 enhances thermogenesis in human neck adipocytes through both UCP1-dependent and independent mechanisms, upregulating genes like ACAN, CRYAB, and ID1.

Mapping of a N-terminal α-helix domain required for human PINK1 stabilisation, Serine228 autophosphorylation and activation in cells

This study identifies an N-terminal α-helix domain in PINK1 critical for its stabilization, autophosphorylation, and activation, linking mutations in this region to Parkinson's disease.

Dissemination and pathogenesis of toxigenic Clostridium perfringens strains linked to neonatal intensive care units and Necrotising Enterocolitis

This study identifies hypervirulent C. perfringens strains linked to NEC in preterm infants, showing their dissemination between hospitals and increased virulence.

Irisin stimulates the release of CXCL1 from differentiating human subcutaneous and deep-neck derived adipocytes via upregulation of NFκB pathway

This study shows irisin increases CXCL1 release from human adipocytes via NFκB pathway activation, enhancing endothelial cell adhesion and potentially improving vascularization.

Amyloid fibril-based hydrogels for high-throughput tumor spheroid modeling

This paper develops amyloid fibril-based hydrogels for 3D tumor spheroid modeling, showing enhanced drug resistance and cancer biomarker expression compared to 2D cultures.

The geometric determinants of programmed antibody migration and binding on multi-antigen substrates

The paper develops a model to simulate antibody-antigen interactions on patterned surfaces and shows antigen spacing influences antibody migration and binding.

Single-molecule diffusometry reveals no catalysis-induced diffusion enhancement of alkaline phosphatase as proposed by FCS experiments

The paper uses single-molecule techniques to show catalysis does not enhance diffusion of alkaline phosphatase, contradicting previous FCS results attributed to substrate-induced dye blinking.

FTO intronic SNP strongly influences human neck adipocyte browning determined by tissue and PPARγ specific regulation: a transcriptome analysis

This study shows that the FTO SNP rs1421085 affects human neck adipocyte browning by regulating PPARγ-dependent gene expression and thermogenic pathways.

Transforming growth factor-beta signaling via ALK1 and ALK5 regulates distinct functional pathways in vein graft intimal hyperplasia

This study shows TGF{beta} signals through ALK1 and ALK5 in vein graft SMCs, with ALK5 promoting contractility and ALK1 driving migration, suggesting balancing these pathways could prevent graft failure.

Microbiota supplementation with Bifidobacterium and Lactobacillus modifies the preterm infant gut microbiota and metabolome

This study shows that supplementing preterm infants with Bifidobacterium and Lactobacillus changes their gut microbiota and increases fecal acetate and lactate levels, resembling a full-term infant's gut environment.

An inordinate fondness for species with intermediate dispersal abilities

The paper shows that species with intermediate dispersal abilities are more likely to achieve high species richness due to eco-evolutionary effects of dispersal on speciation.