S. Poliska

Human Abdominal Subcutaneous-Derived Active Beige Adipocytes Carrying FTO rs1421085 Obesity-Risk Alleles Exert Lower Thermogenic Capacity

The paper investigates how FTO rs1421085 obesity-risk alleles affect thermogenic capacity in human beige adipocytes, finding reduced thermogenesis and gene expression in CC carriers.

BMP7 increases UCP1-dependent and independent thermogenesis with a unique gene expression program in human neck area derived adipocytes

This study shows BMP7 enhances thermogenesis in human neck adipocytes through both UCP1-dependent and independent mechanisms, upregulating genes like ACAN, CRYAB, and ID1.

Irisin stimulates the release of CXCL1 from differentiating human subcutaneous and deep-neck derived adipocytes via upregulation of NFκB pathway

This study shows irisin increases CXCL1 release from human adipocytes via NFκB pathway activation, enhancing endothelial cell adhesion and potentially improving vascularization.

The cryptic gonadotropin-releasing hormone neuronal system of human basal ganglia

The paper identifies and characterizes extrahypothalamic GnRH neurons in human basal ganglia and basal forebrain, revealing their cholinergic nature and potential therapeutic relevance in neurodegenerative diseases.

EPIGENETIC MODULATION VIA THE C-TERMINAL TAIL OF H2A.Z

The paper shows that the C-terminal tail of H2A.Z affects nucleosome stability and chromatin structure, with targeted peptides altering gene expression and chromatin sensitivity.

FTO intronic SNP strongly influences human neck adipocyte browning determined by tissue and PPARγ specific regulation: a transcriptome analysis

This study shows that the FTO SNP rs1421085 affects human neck adipocyte browning by regulating PPARγ-dependent gene expression and thermogenic pathways.