Structural Basis of H2B Ubiquitination-Dependent H3K4 Methylation by COMPASS
P. L. Hsu, H. Shi, C. Leonen, J. Kang, C. Chatterjee, N. Zheng
This study determines the cryo-EM structure of the COMPASS complex bound to H2Bub and nucleosome, revealing how H2Bub activates H3K4 methylation by modulating the Set1 ARM.
bioRxiv · Aug 20, 2019Biochemistry