J. Kang

Limosilactobacillus fermentum ATG-V5 stimulates the immune response by enhancing gut microbiome and metabolite in a cyclophosphamide-induced immunosuppression mouse model

This study shows that Limosilactobacillus fermentum ATG-V5 enhances immune response in a cyclophosphamide-induced immunosuppression mouse model by modulating gut microbiota and metabolites.

Misspellings or miscellings- non-verifiable cell lines in cancer research publications

The paper identifies non-verifiable human cell lines in cancer research publications, finding 235 papers referring to 7 cell lines as independent entities despite lacking proper documentation.

Mapping protein-metabolite interactions in E. coli by integrating chromatographic techniques and co-fractionation mass spectrometry.

The paper introduces PROMIS, a co-fractionation mass spectrometry technique integrated with chromatographic methods to map protein-metabolite interactions in E. coli, identifying 994 interactions and revealing novel functional insights.

Human Amniotic Epithelial Cells Promote Chx10-/Pax6+ Muller Glia Subpopulation Reprogramming into Photoreceptor-like Cells

This study identifies a specific Muller glia subpopulation that can be reprogrammed into photoreceptor-like cells through transplantation of human amniotic epithelial cells.

Capsaicin acts as a novel NRF2 agonist to suppress ethanol induced gastric mucosa oxidative damage by directly disrupting the KEAP1-NRF2 interaction

This study shows capsaicin directly binds KEAP1 and allosterically activates NRF2, reducing ethanol-induced gastric oxidative damage and suggesting its potential as a novel NRF2 agonist for oxidative stress-related diseases.

Identifying drug sensitivity of multifocal primary prostate cancer

This study uses patient-derived organoids to investigate drug sensitivity in multifocal prostate cancer and develops a transcriptomics-based model to predict drug responses.

ATP energy-independentlymodulates the folding equilibrium of ALScausing C71G-hPFN1

This study investigates how ATP modulates the folding equilibrium of the ALS-causing C71G-hPFN1 mutant, revealing its role in inducing folding, inhibiting aggregation, and increasing stability.

Anti-muscle Atrophy Effects of Lactobacillus reuteri ATG-F4 and Its Impact on Intestinal Microbiota and Metabolites: Implications for Prophylaxis and Therapy

This study shows that Lactobacillus reuteri ATG-F4 reduces muscle atrophy by altering gut microbiota and metabolites, with anti-inflammatory effects.

Intrarenal myeloid subsets associated with kidney injury are comparable in mice and patients with lupus nephritis

This study identifies conserved myeloid subsets and disease-associated gene expression changes in kidney injury across lupus mouse models and human patients with lupus nephritis.

Theoretical framework and experimental solution for the air-water interface adsorption problem in cryoEM

The paper develops a theoretical framework explaining particle behavior at the air-water interface in cryoEM and validates it experimentally using surfactants to improve structural determination.

Only Zn2+ and Fe2+ out of 12 cations can fold ALS-linked nascent hSOD1

This paper identifies Zn2+ and Fe2+ as the only cations among 12 tested that can induce folding of nascent hSOD1, with implications for ALS pathogenesis.

Embryonic type 3 innate lymphoid cells sense maternal dietary cholesterol to control local Peyer's patch development

The paper identifies how maternal dietary cholesterol influences Peyer's patch development through LTi cell GPR183 sensing of 7,25-HC.

Dopamine promotes Klebsiella quasivariicola proliferation and inflammatory response in the presence of macrophages

This study shows dopamine promotes Klebsiella quasivariicola growth and inflammation in macrophage co-culture, exacerbating lung injury in mice.

Quantitative proteomics combined with network pharmacology analysis unveils the biological basis of Schisandrin B in treating diabetic nephropathy

This study identifies the mechanisms of Schisandrin B in treating diabetic nephropathy using network pharmacology and quantitative proteomics in rats.

The Geometric Evolution of Aortic Dissections: Predicting Surgical Success using Fluctuations in Integrated Gaussian Curvature

This paper introduces a geometric descriptor based on integrated Gaussian curvature to predict surgical success in aortic dissections by analyzing shape changes.

Visualizing proteins by expansion microscopy

This paper introduces ONE microscopy, a technique that enables nanoscale imaging of single proteins and molecular complexes, revealing structural details in cells and disease samples.

Cardiac-Gated Spectroscopic Photoacoustic Imaging for Ablation-Induced Necrotic Lesion Visualization: In Vivo Demonstration in a Beating Heart

This paper demonstrates cardiac-gated spectroscopic photoacoustic imaging for visualizing ablation-induced necrotic lesions in a beating heart using a swine model.

Spatiotemporal landscape of SARS-CoV-2 pulmonary infection reveals Slamf9+Spp1+ macrophages promoting viral clearance and inflammation resolution

This study identifies Slamf9+Spp1+ macrophages in hamsters that promote SARS-CoV-2 clearance and inflammation resolution through spatial transcriptomics and scRNA-seq.

Exercise reprograms the inflammatory landscape of multiple stem cell compartments during mammalian aging

This study examines how exercise affects stem cell compartments and immune cells in aging mice, identifying rejuvenating effects and transcriptomic changes.

Comprehensive antibody profiling of mRNA vaccination in children

This study compares humoral immune responses to mRNA vaccines in children aged 6-11 years, finding that a 100g dose elicits robust and dose-dependent cross-VOC antibody responses with preserved functional immunity.

Transcranial photoacoustic characterization of neurovascular physiology during early-stage photothrombotic stroke in neonatal piglets in vivo

This study uses transcranial photoacoustic imaging to detect early-stage photothrombotic stroke in neonatal piglets, finding that HbO2 saturation can distinguish affected from control brain regions.

Cystathionine-β-synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation

This study shows that Cystathionine-β-synthase (CBS) maintains AKT-induced senescence and suppresses gastric cancer growth in PI3K/AKT-activated cells.

Mucosal immunization with DTaP confers protection against Bordetella pertussis infection and cough in Sprague-Dawley rats

This study shows that mucosal vaccination with aP protects against Bp infection and cough in rats, inducing mucosal immunity and reducing bacterial burden.

Identification of DIR1-dependant cellular responses required for guard cell systemic acquired resistance

The paper identifies DIR1-dependent molecular changes in guard cells during systemic acquired resistance using multi-omics, revealing two 18C fatty acids as potential SAR-related molecules.

Early cross-coronavirus reactive signatures of protective humoral immunity against COVID-19

The paper profiles early humoral immune responses in COVID-19 patients, finding that survivors show rapid SARS-CoV-2-specific immunity linked to pre-existing OC43 immunity, while non-survivors have delayed and blunted responses.

Potential transmission chains of variant B.1.1.7 and co-mutations of SARS-CoV-2

The paper analyzes SARS-CoV-2 mutations and co-mutations, suggesting Canidae as a possible host for the B.1.1.7 variant and showing that co-mutations significantly reduce viral replication.

Re-investigating the coughing rat model of pertussis to understand Bordetella pertussis pathogenesis

This study uses a rat model to compare disease manifestations between two genetically distinct Bordetella pertussis strains, finding that D420 induces more severe coughing and immune responses than Tohama 1.

Assembly of chromosome-scale and allele-aware autotetraploid genome of the Chinese alfalfa cultivar Zhongmu-4 and identification of SNP loci associated with 27 agronomic traits

The paper assembles a chromosome-scale, allele-aware autotetraploid genome of alfalfa cultivar Zhongmu-4 and identifies 101 SNPs associated with 27 agronomic traits using GWAS.

Crowdsourced identification of multi-target kinase inhibitors for RET- and TAU- based disease: the Multi-Targeting Drug DREAM Challenge

The paper reports on a DREAM Challenge to predict multi-target kinase inhibitors for RET-based tumors and Tauopathy, using neural network-based machine learning approaches.

Novel inhibitors of E. coli lipoprotein diacylglyceryl transferase are insensitive to resistance caused by lpp deletion

The paper identifies Lgt inhibitors that remain effective against E. coli even when lpp is deleted, showing Lgt is a robust antibacterial target.