H. Shi

Inter-domain flexibility in F-Box proteins revealed by integrative modeling

The paper uses integrative modeling to reveal inter-domain flexibility in F-box proteins, showing varying conformational dynamics across different F-box proteins.

TAK1-mediated phosphorylation of PLCE1 represses PIP2 hydrolysis to impede esophageal squamous cancer metastasis

This study shows that TAK1 phosphorylates PLCE1 at S1060, reducing PIP2 hydrolysis and inhibiting esophageal squamous cancer metastasis.

Multi-COBRA hemagglutinin formulated with cGAMP microparticles elicit protective immune responses against influenza viruses

This study evaluates COBRA vaccines formulated with cGAMP microparticles in mice, showing enhanced antibody responses and protection against influenza viruses.

Jianpi Jiedu Recipe inhibits proliferation through reactive oxygen species-induced incomplete autophagy and reduces PD-L1 expression in colon cancer

Identification of retinal tau oligomers, citrullinated tau, and other tau isoforms in early and advanced AD and relations to disease status

This study quantifies retinal tau isoforms in early and advanced AD and links them to brain pathology and cognitive status.

Degradation of indole-3-acetic acid by plant-associated microbes

This study identifies bacterial isolates capable of degrading indole-3-acetic acid (IAA) from Arabidopsis and rice roots, revealing their functional roles and association with IAA producers.

Granulosa cell-layer stiffening prevents the granulosa cells from escaping the post-ovulatory follicle

The paper shows that granulosa cell-layer stiffening, driven by focal adhesion assembly and LH signaling, prevents granulosa cells from escaping the post-ovulatory follicle.

Loss of TIM4-Dependent Efferocytosis in Kupffer CellsPromotes Liver Fibrosis in Nonalcoholic Steatohepatitis

This study shows that loss of TIM4 in Kupffer cells impairs efferocytosis of apoptotic hepatocytes in NASH, promoting liver fibrosis, and that restoring TIM4 reduces fibrosis.

Effects of different feeding methods on serum biochemical indexes, metabolic indexes, immune indexes, and intestinal microorganisms of Nanjiang yellow goats

This study examines how different feeding methods affect serum biochemical, immune, and metabolic indicators and intestinal microbiota in Nanjiang Yellow goats, finding significant differences in metabolites, immune factors, and microbial composition.

Lrp10 suppresses IL7R limiting CD8 T cell homeostatic expansion and anti-tumor immunity.

This study identifies Lrp10 as a negative regulator of CD8 T cell homeostasis and tumor resistance by suppressing IL7R levels and enhancing anti-tumor immunity.

Omics-assisted systematic exploration of the intricate regulatory network of guvermectin biosynthesis centered by the cluster-situated regulator GvmR in Streptomyces

The paper identifies GvmR as a key regulator of guvermectin biosynthesis in Streptomyces, revealing its interactions with other regulators and pathways involved in precursor supply and energy synthesis.

Berberine impairs spermatogenesis in mice by modulating ornithine metabolism via gut microbiota regulation

This study shows berberine reduces sperm count and testosterone in mice by altering gut microbiota, specifically reducing Muribaculaceae, and affecting ornithine metabolism.

Hepatocyte-Targeted siTAZ Therapy Lowers Liver Fibrosis in NASH Diet-Fed Chimeric Mice with Hepatocyte-Humanized Livers

PD-L1 Restrains the PD-1hiNrp1loTGFb+ Treg to block IL6+ Neutrophil tumor infiltration to Suppress Inflammation-driven Colorectal Cancer

This study shows PD-L1 suppresses inflammation-driven colorectal cancer by regulating Tregs, neutrophils, and gut microbiota through the PD-L1/L. murinus/PD-1hiNrp1loTGFβ+ Treg/IL6+ neutrophils pathway.

PROTAC-mediated Degradation of HIV-1 Nef Efficiently Restores Cell-surface CD4 and MHC-I Expression and Blocks HIV-1 Replication

This study develops PROTACs to degrade HIV-1 Nef, restoring CD4 and MHC-I expression and inhibiting HIV-1 replication in T cells and PBMCs.

Hepatocyte-specific disruption of soluble epoxide hydrolase attenuates abdominal aortic aneurysm formation: novel role of the liver in aneurysm pathogenesis

This study shows that disrupting soluble epoxide hydrolase (sEH) in the liver prevents abdominal aortic aneurysm (AAA) formation by reducing inflammatory factors like C3 and SAA.

Spatial Mapping of Mobile Genetic Elements and their Cognate Hosts in Complex Microbiomes

The paper develops an imaging method to map mobile genetic elements and their bacterial hosts in human oral biofilms, revealing spatial clusters of AMR plasmids and prophage.

In vivo Ontogeny of human forebrain neural progenitor cell grafts in adult rats: an immunohistological study

This study tracks human neural progenitor cell grafts in adult rats up to 9 months, revealing their migration and differentiation patterns, and highlights their potential for neural repair.

Single-cell DNA replication dynamics in genomically unstable cancers

The paper develops a method to infer DNA replication states from single-cell sequencing and analyzes replication dynamics in aneuploid cancers, finding correlations between replication timing and copy number changes.

Genetic Predisposition to Neuroblastoma Results from a Regulatory Polymorphism that Promotes the Adrenergic Cell State

The paper identifies a regulatory polymorphism in LMO1 that reduces neuroblastoma risk by preventing the adrenergic cell state in zebrafish and humans.

Exploiting allele-specific transcriptional effects of subclonal copy number alterations for genotype-phenotype mapping in cancer cell populations

This paper develops TreeAlign to map subclonal copy number alterations to transcriptional phenotypes in cancer cells, showing improved accuracy in clone-specific gene expression analysis.

Leptospermum extract (QV0) suppresses pleural mesothelioma tumour growth in vitro and in vivo by mitochondrial dysfunction associated apoptosis

This study shows that Leptospermum extract (QV0) reduces pleural mesothelioma tumour growth in vitro and in vivo by inducing mitochondrial dysfunction and apoptosis without adverse effects.

A Fast Solution for Automated Single-Molecule Force Spectroscopy Data Collection and Processing

The paper develops an automated software tool for processing single-molecule force spectroscopy data, improving efficiency and reducing errors in fitting force-extension curves.

Improved Genome Editing by an Engineered CRISPR-Cas12a

This paper improves CRISPR-Cas12a genome editing by combining rational engineering and directed evolution to enhance homology-directed repair efficiency.

Modulation of bacterial cell size and growth rate via activation of a cell envelope stress response

This study shows that activating the Rcs phosphorelay in E. coli reduces growth rate and alters FtsZ distribution, with effects mediated through growth-rate changes rather than direct regulation.

Bacterial cell widening alters periplasmic size and activates envelope stress responses

This study shows that changes in bacterial cell width affect periplasmic thickness and activate the Rcs stress response system through RcsF.

SP1 affects the migration and invasion of laryngeal cancer cells by regulating methylation of claudin 4 promoter region through the p-JNK pathway

This study shows SP1 regulates CLDN4 promoter methylation via the p-JNK pathway, increasing MMP-2/MMP-9 expression and enhancing laryngeal cancer cell migration and invasion.

A dynamic kissing model for enhancer-promoter communication on the surface of transcriptional condensate

The paper proposes a dynamic kissing model for enhancer-promoter communication within transcriptional condensates, supported by experimental data showing preference for spherical surface confinement.

Comparative evaluation of glomerular morphometric techniques reveals differential technical artefacts between FSGS and normal glomeruli

This study evaluates glomerular morphometric techniques, finding that 10-glomerular sampling is sufficiently precise and that paraffin-embedding causes shrinkage bias affecting FSGS and normal glomeruli differently.

Profiling of the human intestinal microbiome and bile acids under physiologic conditions using an ingestible sampling device

The paper develops an ingestible device to collect intestinal samples and identifies regional differences in microbiota and bile acids compared to stool.