A conserved uORF regulates APOBEC3G translation and is targeted by HIV-1 Vif protein to repress the antiviral factor
C. Libre, T. Seissler, S. Guerrero, J. Batisse, C. Verriez, B. Stupfler, O. Gilmer, R. Cabrera-Rodriguez, M. M. Weber, A. Valenzuela-Fernandez, A. Cimarelli, L. Etienne, R. Marquet, J.-C. Paillart
The paper identifies a conserved upstream ORF (uORF) in APOBEC3G mRNA that regulates its translation and is targeted by HIV-1 Vif to suppress antiviral activity.
bioRxiv · Jan 13, 2021Microbiology