L. Etienne

Exploring the role of cultivar, year and plot age in the incidence of esca and Eutypa dieback: insights from 20 years of regional surveys in France

The paper analyzes 20 years of regional survey data from France to assess the impact of cultivar, year, and plot age on esca and Eutypa dieback incidence in grapevines.

Deciphering lentiviral Vpr/Vpx determinants required for HUSH and SAMHD1 antagonism highlights the molecular plasticity of these evolutionary conflicts

This study identifies viral determinants in Vpr and Vpx proteins that enable antagonism of SAMHD1 and HUSH, revealing molecular plasticity in lentiviral adaptation to host restrictions.

MORC2 restriction factor silences HIV proviral expression

This study identifies MORC2 as a negative regulator of HIV-1 provirus expression, showing it is recruited to the provirus locus and required for HUSH-mediated silencing.

Recognition and Cleavage of Human tRNA Methyltransferase TRMT1 by the SARS-CoV-2 Main Protease

This study identifies TRMT1 as a target of SARS-CoV-2 Mpro, showing cleavage disrupts its tRNA methyltransferase activity and impacts host translation and oxidative stress response.

The inflammatory and tumor suppressor SAMD9L acts through a Schlafen-like box to restrict HIV and inhibit cell translation in SAAD/ATXPC

This paper identifies SAMD9L as an HIV-1 restriction factor that inhibits viral and cellular translation through a Schlafen-like box, with implications for HIV/AIDS and genetic diseases.

Adaptive duplication and functional diversification of Protein kinase R contribute to the uniqueness of bat-virus interactions

This study shows that bat PKR genes have evolved through duplication and functional diversification, enabling unique antiviral defenses against DNA and RNA viruses.

Trim69 is a microtubule regulator that acts as a pantropic viral inhibitor

The paper identifies Trim69 as a microtubule regulator that inhibits multiple viruses by stabilizing microtubules in IFN-stimulated myeloid cells.

Extensive uORF translation from HIV-1 transcripts conditions DDX3 dependency for expression of main ORFs and elicits specific T cell immune responses in infected individuals

The paper characterizes HIV-1 translational landscape, revealing uORF translation and its role in DDX3 dependency and T cell immune responses.

Distinct evolutionary trajectories of SARS-CoV-2 interacting proteins in bats and primates identify important host determinants of COVID-19

This paper identifies evolutionary adaptations in SARS-CoV-2 interacting proteins in bats and primates, revealing host-specific determinants of viral susceptibility and COVID-19 severity.

A conserved uORF regulates APOBEC3G translation and is targeted by HIV-1 Vif protein to repress the antiviral factor

The paper identifies a conserved upstream ORF (uORF) in APOBEC3G mRNA that regulates its translation and is targeted by HIV-1 Vif to suppress antiviral activity.

Rapid evolution of mammalian HERC6 and independent duplication of a chimeric HERC5/6 gene in rodents and bats suggest an overlooked role of HERCs in antiviral innate immunity

This study identifies rapid evolutionary changes in HERC5 and HERC6 genes across mammals, revealing adaptive evolution in HERC6 and a chimeric HERC5/6 gene in rodents and bats, suggesting roles in antiviral immunity.

DGINN, an automated and highly-flexible pipeline for the Detection of Genetic INNovations on protein-coding genes

DGINN automates the detection of genetic innovations and adaptive evolution in protein-coding genes using multiple methods and validates it on primate genes.

Smc5/6-antagonism by HBx is an evolutionary-conserved function of hepatitis B virus infection in mammals

This study shows HBx from diverse hepadnaviruses inactivates Smc5/6 in mammals, suggesting this is an evolutionary-conserved antiviral mechanism.