A. Cimarelli

Deciphering lentiviral Vpr/Vpx determinants required for HUSH and SAMHD1 antagonism highlights the molecular plasticity of these evolutionary conflicts

This study identifies viral determinants in Vpr and Vpx proteins that enable antagonism of SAMHD1 and HUSH, revealing molecular plasticity in lentiviral adaptation to host restrictions.

Stable Structures or poly(A)-binding protein loading protect cellular and viral RNAs against ISG20-mediated decay

The paper identifies PABP1 loading and terminal stem-loop structures as factors protecting RNAs from ISG20-mediated decay, with implications for both cellular and viral RNAs.

MORC2 restriction factor silences HIV proviral expression

This study identifies MORC2 as a negative regulator of HIV-1 provirus expression, showing it is recruited to the provirus locus and required for HUSH-mediated silencing.

The inflammatory and tumor suppressor SAMD9L acts through a Schlafen-like box to restrict HIV and inhibit cell translation in SAAD/ATXPC

This paper identifies SAMD9L as an HIV-1 restriction factor that inhibits viral and cellular translation through a Schlafen-like box, with implications for HIV/AIDS and genetic diseases.

Adaptive duplication and functional diversification of Protein kinase R contribute to the uniqueness of bat-virus interactions

This study shows that bat PKR genes have evolved through duplication and functional diversification, enabling unique antiviral defenses against DNA and RNA viruses.

Trim69 is a microtubule regulator that acts as a pantropic viral inhibitor

The paper identifies Trim69 as a microtubule regulator that inhibits multiple viruses by stabilizing microtubules in IFN-stimulated myeloid cells.

Distinct evolutionary trajectories of SARS-CoV-2 interacting proteins in bats and primates identify important host determinants of COVID-19

This paper identifies evolutionary adaptations in SARS-CoV-2 interacting proteins in bats and primates, revealing host-specific determinants of viral susceptibility and COVID-19 severity.

A novel domain within the CIL regulates egress of IFITM3 from the Golgi and prevents its deleterious accumulation in this apparatus

This study identifies a novel domain in IFITM3 that regulates its egress from the Golgi and prevents membrane fusion inhibition and Golgi dysfunction.

A conserved uORF regulates APOBEC3G translation and is targeted by HIV-1 Vif protein to repress the antiviral factor

The paper identifies a conserved upstream ORF (uORF) in APOBEC3G mRNA that regulates its translation and is targeted by HIV-1 Vif to suppress antiviral activity.

DGINN, an automated and highly-flexible pipeline for the Detection of Genetic INNovations on protein-coding genes

DGINN automates the detection of genetic innovations and adaptive evolution in protein-coding genes using multiple methods and validates it on primate genes.