Therapeutic vulnerability to PARP1/2 inhibition in RB1-mutant osteosarcoma
G. Zoumpoulidou, C. A. Mendoza, C. Mancusi, R. M. Ahmed, M. Denman, C. D. Steele, J. Manji, N. Pillay, S. J. Strauss, S. Mittnacht
This study shows RB1-mutant osteosarcoma is hypersensitive to PARP1/2 inhibitors, with sensitivity linked to replication checkpoint activation rather than homologous repair defects.
bioRxiv · Dec 28, 2020 · PreprintCancer Biology