Author

C. D. Steele

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Organism:human· 5 Assay:whole-genome sequencing· 4 Approach:experimental assay· 3 Approach:statistical model· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2 Research Focus:variant calling· 2

Frequent Co-Authors

N. Pillay· 4 shared A. M. Flanagan· 2 shared L. B. Alexandrov· 2 shared A. Abbasi· 1 shared A. Al-Ibraheemi· 1 shared A. C. Hirbe· 1 shared A. Chatzipli· 1 shared A. Feber· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersCancer Biology

N. Pillay

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Author profile →

5 papers

Recent·Most cited

Mitotic tethering enables en masse inheritance of a shattered micronuclear chromosome

D. W. Cleveland, P. Trivedi, C. D. Steele, L. B. Alexandrov

The paper shows that mitotic tethering by MDC1, TOPBP1, and CIP2A enables en masse inheritance of chromothriptic chromosome fragments, contributing to cancer genome evolution.

bioRxiv · Sep 8, 2022Cancer Biology

Genomic patterns of malignant peripheral nerve sheath tumour (MPNST) evolution correlate with clinical outcome and are detectable in cell-free DNA

I. Cortes-Ciriano, C. D. Steele, K. G. Piculell, A. Al-Ibraheemi, V. Eulo, M. M. Bui, A. Chatzipli, B. C. Dickson, D. C. Borcherding, A. Feber, A. Galor, J. Hart, K. B. Jones, J. T. Jordan, R. H. Kim, , D. T. Miller

This study identifies genomic patterns in MPNST evolution linked to clinical outcomes and shows these patterns are detectable in cell-free DNA.

bioRxiv · May 3, 2022 · PreprintCancer Biology

Mutation Rate Evolution Drives Immune Escape In Mismatch Repair-Deficient Cancer

H. Kayhanian, P. Barmpoutis, E. Lakatos, W. C. H. Cross, G. Caravagna, L. Zapata, K. Litchfield, C. D. Steele, W. Waddingham, D. Patel, S. Milite, C. Jin, A.-M. Baker, C. Ross, D. Alexander, , M. Jansen

The paper shows that mutation rate adaptation in MMRd cancers drives immune escape by modulating neoantigen diversity and subclonal mutation rates.

bioRxiv · Mar 6, 2022 · PreprintCancer Biology

Signatures of copy number alterations in human cancer

C. D. Steele, A. Abbasi, A. S. M. Islam, A. Khandekar, K. Haase, S. Hames, M. Tarabichi, T. Lesluyes, A. M. Flanagan, F. Mertens, P. Van Loo, L. B. Alexandrov, N. Pillay

This paper identifies 19 copy number signatures in 9,873 cancers, explaining 93% of TCGA samples, and reveals diverse mechanisms underlying copy number alterations in human cancer.

bioRxiv · Apr 30, 2021Cancer Biology

Therapeutic vulnerability to PARP1/2 inhibition in RB1-mutant osteosarcoma

G. Zoumpoulidou, C. A. Mendoza, C. Mancusi, R. M. Ahmed, M. Denman, C. D. Steele, J. Manji, N. Pillay, S. J. Strauss, S. Mittnacht

This study shows RB1-mutant osteosarcoma is hypersensitive to PARP1/2 inhibitors, with sensitivity linked to replication checkpoint activation rather than homologous repair defects.

bioRxiv · Dec 28, 2020 · PreprintCancer Biology