Divergent MEK/ERK and AMPK signaling dictate lipogenic plasticity and dependence on fatty acid synthesis in Glioblastoma
K. Eyme, A. Sammarco, R. Jha, H. MNATSAKANYAN, R. Neustadt, C. Moses, A. Alnasser, D. Tardiff, B. Su, K. Williams, S. Bensinger, C. Y. Chung, c. E. badr
This study identifies that MEK/ERK and AMPK signaling regulate lipogenic plasticity in Glioblastoma stem-like cells, influencing their dependence on fatty acid synthesis and response to DNLS inhibitors.
bioRxiv · Apr 7, 2022 · PreprintCancer Biology