K. Williams

A diverse proteome is present and enzymatically active in metabolite extracts

The paper shows that metabolite extracts contain active enzymes and demonstrates a new workflow to remove proteins for improved metabolomics.

Post-transcriptional regulation of the MiaA prenyl transferase by CsrA and the small RNA CsrB in E. coli

The paper identifies CsrA and CsrB as post-transcriptional regulators of miaA in E. coli, showing CsrA binds MiaA mRNA and CsrB sequesters CsrA, affecting MiaA expression and tRNA modification.

Structural enrichment attenuates colitis-associated colon cancer

The paper investigates how enriched versus impoverished housing conditions affect tumorigenesis in a mouse model of colitis-associated colon cancer, finding enriched housing reduces tumor burden.

A female-biased gene expression signature of dominance in cooperatively breeding meerkats

The paper identifies a female-biased gene expression signature of dominance in meerkats, showing differential gene expression in females but not males, with implications for social status and life history trade-offs.

The Impact of SIV-Induced Immunodeficiency on Clinical Manifestation, Immune Response, and Viral Dynamics in SARS-CoV-2 Coinfection

This study examines how SIV-induced immunodeficiency affects SARS-CoV-2 infection in macaques, finding that while immune responses are impaired, viral kinetics and evolution remain unchanged.

Immune Correlates of Hyperglycemia and Vaccination in a Non-human Primate Model of Long-COVID

This study establishes a non-human primate model of metabolic PASC, identifies immune correlates of hyperglycemia, and shows vaccine-induced glycemic improvement.

Metabolomic approaches highlight two mechanisms of accelerated grain filling in Mediterranean oat (Avena sativa L.) cultivars during drought.

This study compares drought responses in two oat cultivars, identifying metabolomic mechanisms underlying accelerated grain filling in a tolerant cultivar.

Integrated Phenomics and Genomics reveals genetic loci associated with inflorescence growth in Brassica napus

The paper identifies genetic loci associated with inflorescence growth traits in Brassica napus using phenomics and genomics integration.

p53 modulates kinase inhibitor resistance and lineage plasticity in NF1-related MPNSTs

This study shows p53 loss in NF1-related MPNSTs leads to MET instability, kinome reprogramming, and therapy resistance through altered signaling and lineage plasticity.

Regionalized protein localization domains in the zebrafish hair cell kinocilium.

The paper identifies three cilia-associated genes in zebrafish hair cells and shows their distinct localization patterns along the kinocilium, suggesting regionalization of the structure.

Lymph node expansion predicts magnitude of vaccine immune response

This study shows that lymph node expansion correlates with vaccine efficacy and immunization outcomes, with strong vaccines causing greater and longer-lasting LN expansion.

Structural and functional changes of pyramidal neurons at the site of an implanted microelectrode array in rat primary motor cortex

This study examines structural and functional changes in pyramidal neurons near implanted microelectrodes in rat motor cortex, finding dendritic disruption, reduced spine density, and altered electrophysiological properties over time.

DNA methyltransferase enhanced Fusobacterium nucleatum genetics

This paper demonstrates using DNA methyltransferases from Fusobacterium nucleatum to bypass restriction-modification systems, enabling efficient genetic modification of previously recalcitrant strains.

Divergent MEK/ERK and AMPK signaling dictate lipogenic plasticity and dependence on fatty acid synthesis in Glioblastoma

This study identifies that MEK/ERK and AMPK signaling regulate lipogenic plasticity in Glioblastoma stem-like cells, influencing their dependence on fatty acid synthesis and response to DNLS inhibitors.

Osteomacs support osteoclast-mediated resorption and contribute to bone pathology in a postmenopausal osteoporosis mouse model

This study identifies osteomacs as supporting osteoclast-mediated bone resorption and contributing to osteoporosis in a postmenopausal mouse model.

The snowmelt niche differentiates three microbial life strategies that influence soil nitrogen availability during and after winter

The paper identifies three microbial life strategies in soil that respond differently to snowmelt, influencing nitrogen availability during and after winter.

Under-the-radar dengue virus infections in natural populations of Aedes aegypti mosquitoes

The paper identifies circulating DENV4 in Aedes aegypti mosquitoes without corresponding human cases, highlighting gaps in current surveillance methods.

Reptile-like physiology in Early Jurassic stem-mammals

The paper uses synchrotron X-ray imaging to show Early Jurassic stem-mammals had lifespans and femoral blood flow rates similar to reptiles, indicating reptile-like physiology rather than endothermic metabolism.

Human cardiac fibrosis-on-a-chip model recapitulates disease hallmarks and can serve as a platform for drug screening

This paper develops a cardiac fibrosis-on-a-chip model that recapitulates fibrosis hallmarks and enables drug screening for anti-fibrotic therapies.

Analysis of Vibrio cholerae genomes using a novel bioinformatic tool identifies new, active Type VI Secretion System gene clusters

The paper develops a bioinformatic tool to identify new T6SS gene clusters in V. cholerae and demonstrates the function of a newly discovered effector protein.

Potential for Methanosarcina to contribute to uranium reduction during acetate-promoted groundwater bioremediation

This study shows Methanosarcina can reduce uranium in groundwater after Fe(III) oxides are depleted, suggesting a new role in bioremediation.