Substrate-assisted Enzymatic Formation of Lysinoalanine in Duramycin
L. An, D. Cogan, C. Navo, G. Jimenez-Oses, S. Nair, W. van der Donk
The paper investigates the mechanism of lysinoalanine formation in duramycin, showing that it is catalyzed by DurN through a substrate-assisted process involving Hya15 as a base.
bioRxiv · Jul 8, 2018Biochemistry