L. An

Atomic context-conditioned protein sequence design using LigandMPNN

This paper introduces LigandMPNN, a deep learning method for protein sequence design that models non-protein atomic contexts, achieving better performance than existing methods in recovering interacting residues.

The evolution of autonomy from two cooperative specialists in fluctuating environments

This study shows that autonomous genotypes can evolve from cooperative microbial specialists in fluctuating environments through horizontal gene transfer.

High immigration rates critical for establishing emigration-driven diversity in microbial communities

The paper investigates how microbial dispersal affects community diversity under competition, finding that high immigration rates enhance diversity through emigration.

De novo design of diverse small molecule binders and sensors using Shape Complementary Pseudocycles

The paper designs nanomolar binders for diverse small molecules using a pseudocycle-based shape complementarity method, enabling direct conversion into sensing systems.

Molecular heterogeneity of quiescent melanocyte stem cells revealed by single-cell RNA-sequencing.

This study uses single-cell RNA sequencing to reveal molecular heterogeneity in quiescent melanocyte stem cells and identifies novel subpopulations with distinct immune privilege and differentiation potential.

Serine hydroxymethyl transferase is a binding target of caprylic acid: Uncovering a novel molecular target for a herbicide and for producing caprylic acid-tolerant crops

This study identifies serine hydroxymethyl transferase (SHMT) as a binding target of caprylic acid, showing its role in herbicidal activity and potential for developing tolerant crops.

Diversity and ecological functions of viruses inhabiting the oil reservoirs

This study identifies a diverse range of viruses in oil reservoirs and their ecological roles in regulating microbial communities and biogeochemical cycles.

Sexual dimorphism in melanocyte stem cell behavior reveals combinational therapeutic strategies for cutaneous repigmentation

The paper identifies sexual dimorphism in melanocyte stem cell behavior and proposes combinational therapy for vitiligo repigmentation.

Keystone taxa responsible for the microbial community stability and performance of activated sludges

The paper identifies keystone taxa in activated sludge microbial communities that enhance stability but reduce function, highlighting the trade-off between stability and performance.

Integration of embryo-endosperm interaction into a holistic and dynamic picture of seed development using a rice mutant with notched-belly grains

The paper investigates embryo-endosperm signaling in rice using a mutant to identify regulatory pathways affecting endosperm development and proposes a new staging system for rice seed development.

High innate preference for black substrate in the chive gnat, Bradysia odoriphaga (Diptera: Sciaridae)

This study shows that chive gnat adults prefer black substrates regardless of color hues, brightness, or ambient light conditions.

Transplantation of human pluripotent stem cells overexpressing insulin/ERRγ can efficiently decrease the HbA1c levels of type 2 diabetes patient (Case #2-A)

Substrate-assisted Enzymatic Formation of Lysinoalanine in Duramycin

The paper investigates the mechanism of lysinoalanine formation in duramycin, showing that it is catalyzed by DurN through a substrate-assisted process involving Hya15 as a base.