W. van der Donk

This study develops a simple method to determine lanthipeptide stereochemistry using Marfeys analysis with low sample requirements and standard equipment.

The paper reports an expression system for producing lanthipeptides and cytolysin L derivatives in mammalian cells and demonstrates their nuclear targeting.

This study shows that the secondary structure of lanthipeptide substrates determines site-selectivity and ring formation order, independent of the dehydration step.

The paper shows that glutamic acid carries hydrazine during the biosynthesis of fosfazinomycin and kinamycin, forming an N-N bond through an acetylhydrazine intermediate.

The paper investigates the mechanism of lysinoalanine formation in duramycin, showing that it is catalyzed by DurN through a substrate-assisted process involving Hya15 as a base.