Metastatic Single Tumor Cells Evade NK Cell-mediated Killing by Thrombin-mediated Loss of the Activating Ligand CD155/PVR/Necl-5
H. Ichise, S. Tsukamoto, T. Hirashima, Y. Konishi, C. Oki, S. Tsukiji, S. Iwano, A. Miyawaki, K. Sumiyama, K. Terai, M. Matsuda
The paper shows metastatic tumor cells evade NK cell killing by losing CD155/PVR/Necl-5 via thrombin, allowing survival in lung capillaries.
bioRxiv · Jan 15, 2021Immunology