M. Matsuda

Importin-7-dependent nuclear localization of the Flavivirus core protein is required for infectious virus production.

This study identifies importin-7 as a nuclear carrier for Flaviviridae core proteins and shows its requirement for infectious virus production.

Calcium transients trigger switch-like discharge of prostaglandin E2 (PGE2) in an extracellular signal-regulated kinase-dependent manner

The paper shows calcium transients trigger switch-like PGE2 discharge in MDCK cells and mouse epidermis, dependent on ERK activity.

A FRET biosensor, SMART, monitors necroptosis in renal tubular epithelial cells in a cisplatin-induced kidney injury model

Dark accumulation of downstream glycolytic intermediates confers robust initiation of photosynthesis in cyanobacteria

The paper shows that accumulation of glycolytic intermediates in the dark enables rapid initiation of photosynthesis in cyanobacteria.

Targeting A-Kinase Anchoring Protein 12 Phosphorylation in Hepatic Stellate Cells Regulates Liver Injury and Fibrosis in Mouse Models

This study shows that targeting AKAP12 phosphorylation in HSCs reduces liver fibrosis by inhibiting collagen maturation and HSC activation in mouse models.

Voltage-Sensing Phosphatase (VSP) Regulates Endocytosis-Dependent Nutrient Absorption in Chordate Enterocytes

This study identifies VSP in absorptive enterocytes, showing its role in promoting endocytosis and nutrient absorption during early development.

Redundant and specific roles of EGFR ligands in the ERK activation waves during collective cell migration of MDCK cells

The paper investigates the roles of EGFR ligands in ERK activation waves during MDCK cell migration, finding redundancy and specific contributions among the ligands.

Lmo7 recruits myosin II heavy chain to induce apical constriction in Xenopus ectoderm

This study identifies Lmo7 as a scaffold that recruits myosin II to apical junctions, promoting apical constriction in Xenopus ectoderm.

Metastatic Single Tumor Cells Evade NK Cell-mediated Killing by Thrombin-mediated Loss of the Activating Ligand CD155/PVR/Necl-5

The paper shows metastatic tumor cells evade NK cell killing by losing CD155/PVR/Necl-5 via thrombin, allowing survival in lung capillaries.

Intravital imaging reveals cell cycle-dependent satellite cell migration during muscle regeneration.

This study uses intravital imaging to show that ERK promotes satellite cell migration during muscle regeneration by facilitating the G1/S transition and enhancing migration speed in the S/G2 phase through CDK2.

ERK-mediated mechanochemical waves direct collective cell polarization

This study shows that ERK-mediated mechanochemical waves coordinate intercellular signaling to direct collective cell migration through long-range polarity alignment.

A parallel cell-cycle entry pathway with inverted G1 signaling and alternate point of no return

The paper identifies an alternate cell-cycle entry pathway with inverted G1 signaling and a new point of no return, demonstrated through single-cell microscopy in cell lines and mice.

Single-cell quantification of the concentration and dissociation constant of endogenous proteins

The paper quantifies endogenous protein concentration and dissociation constant in living cells using CRISPR/Cas9 and FCCS, revealing dynamic changes in protein interactions.

Cell-to-cell heterogeneity in p38-mediated cross-inhibition of JNK causes stochastic cell death

The paper investigates how p38 cross-inhibits JNK, leading to cell-to-cell variability in JNK activity and contributing to stochastic cell death under stress.