Pharmacologic inhibition of lysine specific demethylase-1 (LSD1) as a therapeutic and immune-sensitization strategy in diffuse intrinsic pontine glioma (DIPG)
C. P. Bailey, M. M. Romero, O. J. Becher, M. Monje, D. A. Lee, L. Wang, J. Chandra
This study evaluates LSD1 inhibitors in DIPG, showing selective cytotoxicity and an immune gene signature linked to NK cell activity, with potential therapeutic implications.
bioRxiv · Jul 2, 2019 · PreprintCancer Biology