Author

M. Monje

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 6 Bioengineering· 1 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 7 Research Focus:cell type annotation· 4 Research Focus:drug response / drug discovery· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2

Frequent Co-Authors

A. A. Shelat· 1 shared A. Aabedi· 1 shared A. Banuelos· 1 shared A. Broniscer· 1 shared A. Choudhury· 1 shared A. Delaidelli· 1 shared A. Egladyous· 1 shared A. Findlay· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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1 shared paperCancer Biology

A. A. Shelat

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Engineered CD47 protects T cells for enhanced antitumor immunity

S. A. Yamada-Hunter, J. Theruvath, B. J. McIntosh, K. A. Freitas, M. T. Radosevich, A. Leruste, S. Dhingra, N. Martinez-Velez, P. Xu, A. Delaidelli, M. H. Desai, Z. Good, L. Labanieh, C. W. Mount, Y. Chen, , C. L. Mackall

This paper engineers a CD47 variant to protect T cells from macrophage clearance, enhancing antitumor efficacy by combining T cell and macrophage activation.

bioRxiv · Jun 20, 2023 · PreprintBioengineering

Remote neuronal activity drives glioma infiltration via Sema4f

E. Huang-Hobbs, Y.-T. Cheng, Y. Ko, E. Luna-Figueroa, B. Lozzi, K. Taylor, M. McDonald, P. He, H.-C. Chen, Y. Yang, E. Maleki, Z.-F. Lee, S. Murali, M. Williamson, D. Choi, , B. Deneen

This study identifies callosal projection neurons as drivers of glioma infiltration through Sema4F-mediated activity-dependent signaling in mouse and human tumors.

bioRxiv · Mar 15, 2023 · PreprintCancer Biology

Neuronal Activity-Dependent Mechanisms of Small Cell Lung Cancer Progression

S. Savchuk, K. Gentry, W. Wang, E. Carleton, B. Yalcin, Y. Liu, E. C. Pavarino, J. LaBelle, A. M. Toland, P. J. Woo, F. Qu, M. G. Filbin, M. A. Krasnow, B. L. Sabatini, J. Sage, , H. S. Venkatesh

This study shows neuronal activity drives SCLC growth in both primary lung tumors and brain metastases through electrical and calcium signaling mechanisms.

bioRxiv · Jan 19, 2023 · PreprintCancer Biology

Kinase-modulated bioluminescent indicators enable noninvasive imaging of drug activity in the brain

Y. Wu, J. Walker, L. Ning, M. Westberg, M. Monje, T. Kirkland, M. Lin, Y. Su

This paper introduces KiMBIs, bioluminescent indicators that enable non-invasive imaging of kinase inhibitor activity in the brain, identifying temuterkib as a promising brain-active ERK inhibitor.

bioRxiv · Dec 30, 2022Pharmacology & Toxicology

A light-gated transcriptional recorder for detecting cell-cell contacts

K. F. Cho, S. M. Gillespie, N. A. Kalogriopoulos, M. A. Quezada, M. Jacko, M. Monje, A. Y. Ting

This paper introduces TRACC, a light-gated transcriptional recorder that detects cell-cell contacts with high specificity and sensitivity in mammalian cells.

bioRxiv · Feb 22, 2022Cell Biology

H3-K27M-Mutant Nucleosomes Interact with MLL1 to Shape the Glioma Epigenetic Landscape

N. Furth, D. Algranati, B. Dassa, O. Beresh, V. Fedyuk, N. Morris, L. Kasper, D. Jones, M. Monje, S. Baker, E. Shema

This study shows H3-K27M mutations alter chromatin marks by affecting PRC2 and MLL1 interactions, leading to bivalent chromatin and supporting glioma development.

bioRxiv · Aug 9, 2021Cancer Biology

Glioblastoma remodeling of neural circuits in the human brain decreases survival

S. Krishna, A. Choudhury, K. Seo, L. Ni, S. Kakaizada, A. Lee, A. Aabedi, C. Cao, R. Sudharshan, A. Egladyous, N. Almeida, H. Venkatesh, A. Findlay, S. Nagarajan, D. Raleigh, , S. Hervey-Jumper

This study shows glioblastomas alter neural circuits in the human brain, reducing survival and impairing cognition through synaptogenic interactions.

bioRxiv · Feb 18, 2021 · PreprintCancer Biology

Patient-Derived Orthotopic Xenografts and Cell Lines from Pediatric High-Grade Glioma Recapitulate the Heterogeneity of Histopathology, Molecular Signatures, and Drug Response

C. He, K. Xu, X. Zhu, P. S. Dunphy, B. Gudenas, W. Lin, N. Twarog, L. D. Hover, C.-H. Kwon, L. H. Kasper, J. Zhang, X. Li, J. Dalton, B. Jonchere, K. S. Mercer, , S. J. Baker

The paper establishes patient-derived orthotopic xenograft models and cell lines from pediatric high-grade glioma that replicate histopathology, molecular signatures, and drug response, providing a resource for research.

bioRxiv · Dec 6, 2020 · PreprintCancer Biology

Pharmacologic inhibition of lysine specific demethylase-1 (LSD1) as a therapeutic and immune-sensitization strategy in diffuse intrinsic pontine glioma (DIPG)

C. P. Bailey, M. M. Romero, O. J. Becher, M. Monje, D. A. Lee, L. Wang, J. Chandra

This study evaluates LSD1 inhibitors in DIPG, showing selective cytotoxicity and an immune gene signature linked to NK cell activity, with potential therapeutic implications.

bioRxiv · Jul 2, 2019 · PreprintCancer Biology