Understanding off-target growth defects introduced to influenza A virus by synonymous recoding
C. P. Sharp, E. H. Thompson, B. Tesla, D. Kurian, P. Simmonds, P. Digard, E. R. Gaunt
This study identifies compensatory mutations that cause replication defects in a CpG-enriched influenza A virus, revealing polymerase slippage and type I interferon induction as key mechanisms.
bioRxiv · Jul 17, 2023 · PreprintMicrobiology