Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
5 papers
Recent·Most cited
C. P. Sharp, E. H. Thompson, B. Tesla…·E. R. Gaunt
This study identifies compensatory mutations that cause replication defects in a CpG-enriched influenza A virus, revealing polymerase slippage and type I interferon induction as key mechanisms.
R. J. Pleass, E. R. Gaunt, P. Blundell, C. Vrettou
The paper synthesizes sialylated Fc fragments that inhibit influenza A virus haemagglutination but enhance viral replication in A549 cells, suggesting unintended pro-inflammatory effects.
C. Sharp, B. H. Thompson, T. J. Nash…·E. R. Gaunt
This paper engineers an influenza A virus with increased CpG content, showing it is attenuated in mice but replication competent in vaccine propagation systems, suggesting a new strategy for live attenuated vaccines.
C. R. Dixon, P. Malik, J. I. de las Heras…·E. C. Schirmer
The paper identifies nuclear STING partners that contribute to innate immune signaling by interacting with IRF3/7 transcription factors and enhancing antiviral responses.
P. Digard, H.-M. Lee, C. Sharp…·E. R. Gaunt
The paper analyzes CpG dinucleotide composition in SARS-CoV-2 and other coronaviruses to understand its role in replication and cross-species transmission.