Targeting NAAA counters dopamine neuron loss and symptom progression in mouse models of Parkinson's disease
F. Palese, S. Pontis, N. Realini, A. Torrens, F. Ahmed, F. Assogna, C. Pellicano, P. Bossu, G. Spalletta, K. N. Green, D. Piomelli
This study shows that inhibiting NAAA, which deactivates PEA, protects dopamine neurons and reduces Parkinson's symptoms in mouse models.
bioRxiv · Feb 10, 2022 · PreprintPharmacology & Toxicology