IL-21 has a critical role in establishing germinal centers by amplifying early B cell proliferation
A. R. Dvorscek, C. I. McKenzie, M. J. Robinson, Z. Ding, C. Pitt, K. O'Donnell, D. Zotos, R. Brink, D. M. Tarlinton, I. Quast
The paper shows IL-21 accelerates B cell proliferation and GC formation by enhancing cell cycle progression and entry, increasing plasma cell output.
bioRxiv · Jan 21, 2022Immunology