Z. Ding

Parallel Analyses by Mass Spectrometry (MS) and Reverse Phase Protein Array (RPPA) Reveal Complementary Proteomic Profiles in Triple-Negative Breast Cancer (TNBC) Patient Tissues and Cell Cultures

The paper compares Mass Spectrometry (MS) and Reverse Phase Protein Array (RPPA) in TNBC samples to assess their performance and identify complementary proteomic profiles.

Stimulation of NCAM1-14.3.3.ζδ-derived Peptide Interaction Fuels Angiogenesis and Osteogenesis in Ageing

This study identifies an endogenous NCAM1-14.3.3.ζδ-derived peptide interaction that promotes angiogenesis and osteogenesis, offering a therapeutic target for age-related bone diseases.

CRISPR-Cas9 Engineered Extracellular Vesicles for the Treatment of Dominant Progressive Hearing Loss

The paper develops a scalable microfluidic electroporation system to load gRNA:Cas9 RNP complexes into extracellular vesicles, achieving effective gene therapy for hearing loss in a mouse model.

Kindlin-2 inhibits TNF/NF-kB-caspase 8 pathway in hepatocytes to maintain liver development and function

This study shows Kindlin-2 inhibits the TNF/NF-kB-caspase 8 pathway in hepatocytes, preventing liver fibrosis and dysfunction, and identifies it as a potential therapeutic target for liver diseases.

Extracellular disintegration of viral proteins as an innovative strategy for developing broad-spectrum antivirals against coronavirus

This paper introduces a new antiviral strategy using hyperanion-grafted enediyne molecules to disintegrate viral proteins, showing effectiveness against SARS-CoV-2 and other coronaviruses.

Cryo-EM structures reveal the activation and substrate recognition mechanism of human enteropeptidase

This study reports cryo-EM structures of human enteropeptidase in multiple states, revealing its activation mechanism and substrate recognition process.

Single-nuclei transcriptomics of dog hippocampus reveals the distinct cellular mechanism of domestication

This study uses single-nuclei transcriptomics to analyze dog hippocampus cell types and identifies convergence between differentially expressed genes and putative positively selected genes related to nervous system development.

IL-21 has a critical role in establishing germinal centers by amplifying early B cell proliferation

The paper shows IL-21 accelerates B cell proliferation and GC formation by enhancing cell cycle progression and entry, increasing plasma cell output.

DENV NS1 and MMP-9 cooperate to induce vascular leakage by altering endothelial cell adhesion and tight junction

This study identifies that DENV NS1 and MMP-9 cooperate to induce vascular leakage by altering endothelial cell adhesion and tight junctions, suggesting MMP-9 as a potential therapeutic target for severe dengue.

Modulating the selective utilization of carbon sources by engineering the 3rd and 4th helices of the DNA-binding domain of catabolite control protein A (CcpA) in Bacillus licheniformis

This study investigates how specific amino acids in the DNA-binding domain of CcpA affect carbon source utilization in Bacillus licheniformis through in vitro and in vivo experiments.

Structural insights into the activation of human calcium-sensing receptor

The paper presents cryo-EM structures of the human calcium-sensing receptor in inactive and active states, revealing structural changes during activation.

Auxin-triggered changes in the Arabidopsis root tip (phospho)proteome reveal novel root growth regulators

The paper identifies novel root growth regulators in Arabidopsis root tips through analysis of auxin-triggered (phospho)proteome changes.

Single-cell transcriptomics defines heterogeneity of epicardial cells and fibroblasts within the infarcted heart

The paper uses single-cell RNA sequencing to identify distinct epicardial stromal cell populations in infarcted mouse hearts and their potential cardiomyogenic properties.

Biodiversity Soup II: A bulk-sample metabarcoding pipeline emphasizing error reduction

This paper introduces a metabarcoding pipeline to reduce errors in bulk-sample sequencing, showing reduced false positives and biases but no recovery of relative-abundance information.

Cryo-EM of mammalian PA28αβ-iCPimmunoproteasome reveals a distinct mechanism of proteasome activation by PA28αβ

This study determines the structure of the mammalian PA28β-iCP immunoproteasome using cryo-EM, revealing a unique mechanism of proteasome activation distinct from constitutive proteasomes.

The YdiU Domain Modulates Bacterial Stress Signaling through Mn2+-dependent UMPylation

This paper identifies YdiU as a Mn2+-dependent UMPylase in Salmonella that modulates chaperone function through UMPylation, enhancing stress resistance.

RIP1 kinase activity promotes steatohepatitis through mediating cell death and inflammation in macrophages

This study shows that RIP1 kinase activity in macrophages drives steatohepatitis by promoting cell death and inflammation, and its inhibition reduces liver injury in NASH models.

MRI tracking reveals selective accumulation of stem cell-derived magneto-extracellular vesicles in sites of injury

This study tracks stem cell-derived extracellular vesicles using MRI to show their selective accumulation at injury sites and protective effects in kidney injury models.

Signature activities of 20S proteasome include degradation of the ubiquitin-tag with the protein under hypoxia

The paper identifies the 20S proteasome's ability to degrade ubiquitin-tagged proteins under hypoxia and shows its role in improving cell survival.

Dscam homophilic specificity is generated by high order cis-multimers coupled with trans self-binding of variable Ig1 in Chelicerata

The paper shows that Dscam isoforms in Chelicerata form cis-multimers and trans-self-bind via Ig1 domains to generate unique homophilic recognition specificities for neuronal self-avoidance.

Distinct architecture and composition of mouse axonemal radial spoke head revealed by cryo-EM

The paper reveals the structure and composition of the mouse axonemal radial spoke head using cryo-EM, showing distinct subunit composition and organization compared to Chlamydomonas.

Peptidoglycan associated cyclic lipopeptide disrupts viral infectivity

The paper identifies surfactin, a cyclic lipopeptide from bacterial peptidoglycan, as a broad-spectrum virucidal compound that disrupts enveloped virus infectivity.

PRH1 mediates ARF7-LBD dependent auxin signaling to regulate lateral root development in Arabidopsis thaliana

This study identifies PRH1 as a target of ARF7 and LBDs in auxin signaling, showing its role in lateral root development through interaction with GATA23.

Functional importance of JMY expression by Sertoli cells in mediating mouse spermatogenesis

This study shows that JMY in Sertoli cells regulates actin organization and vesicle trafficking, essential for spermatogenesis, and its disruption causes male subfertility.

Targeting posttranslational modifications of RioK1 inhibits the progression of colorectal and gastric cancers

This study identifies posttranslational modifications of RioK1 that regulate its stability and oncogenic activity in colorectal and gastric cancers.