The PNUTS-PAD domain recruits MYC to the PNUTS:PP1 phosphatase complex via the oncogenic MYC-MB0 region
Y. Wei, A. Ahlner, C. Redel, A. Lemak, I. Johansson-Akhe, S. Houliston, T. M. G. Kenney, A. Tamachi, V. Morad, S. Duan, D. W. Andrews, B. Wallner, M. Sunnerhagen, C. H. Arrowsmith, L. Z. Penn
This paper identifies the MB0 region of MYC as a direct binder to the PNUTS amino-terminal domain (PAD), revealing a molecular mechanism for MYC regulation by the PNUTS:PP1 phosphatase complex.
bioRxiv · Dec 2, 2021Cancer Biology