Targeting MOG to skin macrophages prevents EAE in macaques through TGFβ-induced peripheral tolerance
C.-M. Fovet, L. Stimmer, V. Contreras, P. Horellou, A. Hubert, N. Seddiki, C. Chapon, S. Tricot, C. Leroy, J. Flament, J. Massonneau, N. Tchitchek, B. 't Hart, S. Zurawski, P. Klucar, , C. Serguera
This paper shows that targeting MOG to skin macrophages via a fusion protein prevents EAE in macaques by inducing TGFβ-mediated peripheral tolerance.
bioRxiv · Mar 9, 2019 · PreprintImmunology