The ZNF687 mutation of Paget's disease associated with giant cell tumour causes severe bone remodelling alteration as a result of a deregulated osteoclast transcriptional program
S. Russo, F. Scotto di Carlo, G. Fortunato, A. Maurizi, A. Teti, D. Licastro, C. Settembre, F. Gianfrancesco
This study identifies a ZNF687 mutation causing Paget's disease by disrupting osteoclast function and bone remodeling in mice.
bioRxiv · Aug 12, 2022Cell Biology