Microbiome and Metabolome driven differentiation of TGF-beta producing Tregs leads to Senescence and HIV latency
K. Ghneim, A. A. Sharma, S. P. Ribeiro, S. Fourati, J. Ahlers, D. Kulpa, X. Xu, J. Brehm, A. Talla, S. Arumugam, S. Darko, B. Rodriguez, C. Shive, R. Cristescu, A. Loboda, , R.-P. Sekaly
The paper identifies cellular senescence and TGF-beta pathways in HIV-infected individuals that contribute to HIV latency and poor immune recovery, suggesting potential therapeutic targets.
bioRxiv · Dec 15, 2020 · PreprintImmunology