Author

B. Rodriguez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 5 Biophysics· 3 Physiology· 2 Ecology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 10 Research Focus:cell type annotation· 7 Approach:experimental assay· 7 Approach:deep learning· 5 Assay:electrophysiology· 4 Approach:statistical model· 4 Research Focus:drug response / drug discovery· 3 Research Focus:host-pathogen & immune response· 3

Frequent Co-Authors

A. Bueno-Orovio· 4 shared A. Crabtree· 3 shared E. Garza-Lopez· 3 shared E. Zaganjor· 3 shared J. Lam· 3 shared K. Neikirk· 3 shared L. Vang· 3 shared Z. J. Wang· 3 shared

Activity by Year

2019-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersBioengineering

A. Bueno-Orovio

Mutual co-authors in cluster

Author profile →

14 papers

Recent·Most cited

Towards prospective in-silico trials in atrial fibrillation: the case of polypharmacological SK and K2P channel block

A. Dasi, L. A. Berg, H. Martinez-Navarro, A. Bueno-Orovio, B. Rodriguez

The paper uses in-silico trials to evaluate the efficacy of SK and K2P channel block in atrial fibrillation, finding that combined block significantly improves cardioversion success.

bioRxiv · Mar 30, 2024 · PreprintBioengineering

In Silico Evaluation of Cell Therapy in Acute versus Chronic Infarction: Role of Automaticity, Heterogeneity and Purkinje in Human

L. L. Riebel, Z. J. Wang, H. Martinez-Navarro, C. Trovato, J. Camps, L. A. Berg, X. Zhou, R. Doste, R. Sachetto Oliveria, R. Weber dos Santos, J. Biasetti, B. Rodriguez

The paper uses human-based modeling to evaluate cell therapy in acute and chronic myocardial infarction, finding that cell heterogeneity and Purkinje system function influence arrhythmia risk.

bioRxiv · Dec 11, 2023Bioengineering

Coupling remote sensing and eDNA to monitor environmental impact: A pilot to quantify the environmental benefits of sustainable agriculture in the Brazilian Amazon

K. Dyson, A. P. Nicolau, K. Tenneson, W. Francesconi, A. Daniels, G. Andrich, B. Caldas, S. Castano, N. de Campos, J. Dilger, V. Guidotti, I. Jaques, I. M. McCullough, A. D. McDevitt, L. Molina, , D. Saah

The paper develops and applies a coupled remote sensing and eDNA approach to assess the environmental impact of sustainable agriculture in the Brazilian Amazon.

bioRxiv · Jul 19, 2023 · PreprintEcology

Mapping gut bacteria into functional niches reveals the ecological structure of human gut microbiomes

L. Anthamatten, P. Rogalla von Bieberstein, C. Thabuis, C. Menzi, M. Reichlin, M. Meola, B. Rodriguez, O. X. Cordero, C. Lacroix, T. de Wouters, G. E. Leventhal

The paper maps gut bacteria into functional niches to reveal the ecological structure of human gut microbiomes, identifying characteristic taxa associated with specific metabolic functions.

bioRxiv · Jul 4, 2023 · PreprintMicrobiology

Defining Mitochondrial Cristae Morphology Changes Induced by Aging in Brown Adipose Tissue

A. Crabtree, K. Neikirk, A. Marshall, L. Vang, D. Stephens, B. Shao, E. Garza-Lopez, J. Lam, B. Rodriguez, M. Mungai, J. Stanley, D. Dean, J. Gaddy, E. Scudese, M. Sweetwyne, , A. Hinton

This study uses 3D electron microscopy to analyze mitochondrial cristae morphology in mouse brown adipose tissue across aging, finding significant structural changes in aged tissue.

bioRxiv · May 12, 2023Biophysics

Human iPSC-CMs and in-silico technologies define mechanisms and accelerate targeted pharmacogenetics in hypertrophic cardiomyopathy

F. Margara, Y. Psaras, Z. J. Wang, M. Schmid, R. Doste, A. Garfinkel, G. G. Repetti, J. Seidman, C. Seidman, B. Rodriguez, C. N. Toepfer, A. Bueno-Orovio

The paper combines human iPSC-CMs and in-silico models to identify genotype-specific pathomechanisms and therapeutic targets in hypertrophic cardiomyopathy.

bioRxiv · Jun 8, 2022 · PreprintBioengineering

Three-Dimensional Mitochondria Reconstructions of Murine Cardiac Muscle Changes in Size Across Aging

Z. Vue, K. Neikirk, L. Vang, E. Garza-Lopez, T. A. Christensen, J.-q. Shao, J. Lam, H. K. Beasley, A. G. Marshall, A. Crabtree, J. Anudokem, B. Rodriguez, B. Kirk, S. Bacevac, T. Barongan, , A. Hinton

This study uses 3D imaging to show that mitochondria in aging mouse hearts lose cristae structure and volume, similar to mutations in MICOS complex genes.

bioRxiv · Apr 23, 2022Biophysics

3D Reconstruction of Murine Mitochondria Exhibits Changes in Structure Across Aging Linked to the MICOS Complex

Z. Vue, E. Garza-Lopez, K. Neikirk, P. Katti, L. Vang, H. K. Beasley, J.-q. Shao, A. G. Marshall, A. Crabtree, A. C. Murphy, B. C. Jenkins, P. Prasad, C. S. Evans, B. T. Taylor, M. Mungai, , Murray

This study examines age-related changes in mitochondrial 3D structure in mouse muscle and heart tissues, linking these changes to the MICOS complex and metabolic alterations.

bioRxiv · Mar 22, 2022Biophysics

Clinical phenotypes in acute and chronic infarction explained through human ventricular electromechanical modelling and simulations

X. Zhou, Z. J. Wang, J. Camps, J. Tomek, A. Santiago, A. Quintanas, M. Vazquez, M. Vaseghi, B. Rodriguez

This paper uses human ventricular electromechanical modelling to explain clinical phenotypes in acute and chronic myocardial infarction, showing that ionic remodelling impacts ECG changes and ejection fraction.

bioRxiv · Feb 15, 2022 · PreprintBioengineering

Microbiome and Metabolome driven differentiation of TGF-beta producing Tregs leads to Senescence and HIV latency

K. Ghneim, A. A. Sharma, S. P. Ribeiro, S. Fourati, J. Ahlers, D. Kulpa, X. Xu, J. Brehm, A. Talla, S. Arumugam, S. Darko, B. Rodriguez, C. Shive, R. Cristescu, A. Loboda, , R.-P. Sekaly

The paper identifies cellular senescence and TGF-beta pathways in HIV-infected individuals that contribute to HIV latency and poor immune recovery, suggesting potential therapeutic targets.

bioRxiv · Dec 15, 2020 · PreprintImmunology

ToR-ORd-dynCl: an update of the ToR-ORd model of human ventricular cardiomyocyte with dynamic intracellular chloride

J. Tomek, A. Bueno-Orovio, B. Rodriguez

The paper updates the ToR-ORd model of human ventricular cardiomyocytes to include dynamic intracellular chloride, improving long-term simulation stability without significant complexity increase.

bioRxiv · Jun 1, 2020 · PreprintPhysiology

Temporal Changes Guided by Mesenchymal Stem Cells on a 3D Microgel Platform Enhances Angiogenesis In Vivo at a Low-Cell Dose

D. Thomas, G. Marsico, I. L. Mohd Isa, A. Thirumaran, X. Chen, B. Lukasz, G. Fontana, B. Rodriguez, M. Marchetti-Deschmann, T. O'Brien, A. Pandit

This study shows that preconditioning mesenchymal stem cells on a 3D microgel platform enhances angiogenesis in vivo at a low-cell dose by modulating extracellular stiffness and integrin signaling.

bioRxiv · May 16, 2020Bioengineering

All-optical electrophysiology refines populations of in silico human iPS-CMs for drug evaluation

M. Paci, E. Passini, A. Klimas, S. Severi, J. Hyttinen, B. Rodriguez, E. Entcheva

This paper combines all-optical electrophysiology with in silico models to refine human hiPS-CMs for drug evaluation, showing accurate prediction of drug effects and adverse events.

bioRxiv · Oct 9, 2019Pharmacology & Toxicology

Perlin Noise Generation of Physiologically Realistic Patterns of Fibrosis

D. Jakes, K. Burrage, C. C. Drovandi, P. Burrage, A. Bueno-Orovio, R. W. dos Santos, B. Rodriguez, B. A. J. Lawson

This paper introduces a computational method to generate physiologically realistic fibrosis patterns, demonstrating its application to cardiac fibrosis and showing micro-scale variability impacts on electrophysiology.

bioRxiv · Jun 19, 2019 · PreprintPhysiology