Author

D. Douek

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Assay:metagenomics· 2 Organism:non-human primate· 2 Approach:statistical model· 2

Frequent Co-Authors

S. Darko· 2 shared A. A. Sharma· 1 shared A. Bar-Or· 1 shared A. Brown· 1 shared A. D. Wells· 1 shared A. Eaton· 1 shared A. Loboda· 1 shared A. Naji· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersImmunology

S. Darko

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Breadth of SARS-CoV-2 Neutralization and Protection Induced by a Nanoparticle Vaccine

D. Li, D. R. Martinez, A. Schäfer, H. Chen, M. Barr, L. L. Sutherland, E. Lee, R. Parks, D. Mielke, W. Edwards, A. Newman, K. W. Bock, M. Minai, B. M. Nagata, M. Gagne, , B. F. Haynes

This study shows a nanoparticle vaccine induces broad neutralizing antibodies against multiple SARS-CoV-2 variants and protects non-human primates and mice from viral challenges.

bioRxiv · Jan 26, 2022Immunology

Durability of immune responses to the BNT162b2 mRNA vaccine

M. Suthar, P. S Arunachalam, M. Hu, N. Reis, M. Trisal, O. Raeber, S. Chinthrajah, M. E. Davis-Gardner, K. Manning, P. Mudvari, S. Godbole, E. Boritz, A. R. Henry, D. Douek, K. Nadeau, , P. Halfmann

This study shows that antibody and T cell responses to the BNT162b2 vaccine wane significantly at 6 months, suggesting a potential need for a third booster dose.

bioRxiv · Sep 30, 2021Immunology

Microbiome and Metabolome driven differentiation of TGF-beta producing Tregs leads to Senescence and HIV latency

K. Ghneim, A. A. Sharma, S. P. Ribeiro, S. Fourati, J. Ahlers, D. Kulpa, X. Xu, J. Brehm, A. Talla, S. Arumugam, S. Darko, B. Rodriguez, C. Shive, R. Cristescu, A. Loboda, , R.-P. Sekaly

The paper identifies cellular senescence and TGF-beta pathways in HIV-infected individuals that contribute to HIV latency and poor immune recovery, suggesting potential therapeutic targets.

bioRxiv · Dec 15, 2020 · PreprintImmunology

The identity of human tissue-emigrant CD8+ T cells

M. Buggert, L. A. Vella, S. Nguyen, V. Wu, T. Sekine, A. Perez-Potti, C. R. Maldini, S. Manne, S. Darko, A. Ransier, L. Kuri-Cervantes, A. Sada Japp, I. Bukh Brody, M. A. Ivarsson, L. Hertwig, , M. R. Betts

The paper characterizes tissue-emigrant CD8+ T cells in humans and non-human primates, revealing distinct migratory behaviors and clonal dynamics.

bioRxiv · Aug 11, 2020Immunology