Breast cancer brain metastases show increased levels of genomic aberration based homologous recombination deficiency scores relative to their corresponding primary tumors
M. Diossy, L. Reiniger, Z. Sztupinszki, M. Krzystanek, K. M. Timms, C. Neff, C. Solimeno, D. Pruss, A. C. Eklund, E. Toth, O. Kiss, O. Rusz, G. Cserni, T. Zombori, B. Szekely, , Z. Szallasi
The paper compares HRD scores in primary breast cancer tumors and their brain metastases, finding higher HRD in metastases, suggesting potential changes in PARP inhibitor therapy strategies.
bioRxiv · Jan 5, 2018Cancer Biology