Author

C. Neff

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:clinical cohort / trial· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. C. Eklund· 1 shared A. Fontenot· 1 shared A. Hawley· 1 shared A. Hoyt-Miggelbrink· 1 shared A. Patel· 1 shared B. Palmer· 1 shared B. Szekely· 1 shared C. Solimeno· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperCancer Biology

A. C. Eklund

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3 papers

Recent·Most cited

Glioblastoma and other intracranial tumors elicit systemic sympathetic hyperactivity that limits immunotherapeutic responses

S. J. Lorrey, L. Wachsmuth, J. Finlay, C. Neff, K. Ayasoufi, J. Waibl Polania, A. Hoyt-Miggelbrink, M. Price, L. Rein, S. Dell, R. Reesman, X. Cui, A. Hawley, E. Lerner, D. Wilkinson, , P. E. Fecci

This study shows that intracranial tumors cause systemic sympathetic hyperactivity, impairing T cell function and limiting immunotherapy, and that beta-adrenergic blockade improves outcomes in mouse models and human patients.

bioRxiv · Nov 2, 2023 · PreprintImmunology

SARS-CoV-2-specific T cells associate with reduced lung function and inflammation in pulmonary post-acute sequalae of SARS-CoV-2

K. Littlefield, R. Watson, J. Schneider, C. Neff, E. Yamada, M. Zhang, T. Campbell, M. Falta, S. Jolley, A. Fontenot, B. Palmer

This study finds that elevated SARS-CoV-2-specific T cells in individuals with pulmonary PASC correlate with increased inflammation and reduced lung function.

bioRxiv · Feb 14, 2022Immunology

Breast cancer brain metastases show increased levels of genomic aberration based homologous recombination deficiency scores relative to their corresponding primary tumors

M. Diossy, L. Reiniger, Z. Sztupinszki, M. Krzystanek, K. M. Timms, C. Neff, C. Solimeno, D. Pruss, A. C. Eklund, E. Toth, O. Kiss, O. Rusz, G. Cserni, T. Zombori, B. Szekely, , Z. Szallasi

The paper compares HRD scores in primary breast cancer tumors and their brain metastases, finding higher HRD in metastases, suggesting potential changes in PARP inhibitor therapy strategies.

bioRxiv · Jan 5, 2018Cancer Biology