CBL mutations promote activation of PI3K/AKT signaling via LYN kinase
R. Belizaire, S. H. J. Koochaki, N. Udeshi, A. Vedder, L. Sun, T. Svinkina, C. Hartigan, C. Stanclift, M. Schenone, S. A. Carr, E. Padron, B. L. Ebert
The paper investigates how CBL mutations drive oncogenesis by enhancing LYN kinase activity and PI3K/AKT signaling, suggesting LYN inhibition as a therapeutic strategy.
bioRxiv · Apr 13, 2020 · PreprintCancer Biology