L. Sun

Human ANP32A/B are SUMOylated and utilized by avian influenza virus NS2 protein to overcome species-specific restriction

This study shows that human ANP32A/B are SUMOylated, enabling avian influenza virus NS2 to enhance polymerase activity and overcome species-specific restrictions.

Negative regulation of APC/C activation by MAPK-mediated attenuation of Cdc20Slp1 under stress

The paper shows that MAPK Pmk1 in fission yeast inhibits APC/C activation by phosphorylating and degrading Slp1Cdc20 under stress, revealing a conserved regulatory mechanism.

Ribosome biogenesis factor AtRRB1 confers pollen heat stress tolerance in Arabidopsis

This study identifies AtRRB1 as a ribosome biogenesis factor that enhances heat stress tolerance in Arabidopsis pollen by supporting protein synthesis and ER function during microspore development.

BRD8 guards the pluripotent state by sensing and maintaining histone acetylation

This study shows BRD8 maintains pluripotency by sensing and maintaining histone acetylation, preventing the conversion of primed EpiSCs to naive ESCs.

Orthogonal IMiD-Degron Pairs Induce Selective Protein Degradation in Cells

The paper designs a selective protein degradation system using bumped IMiD analogs and zinc-finger degrons to target specific proteins without affecting endogenous substrates.

Functional and evolutionary integration of a fungal gene with a bacterial operon

The paper shows that the fungal gene ENB1, acquired from a bacterial operon, enables iron uptake in W/S clade yeasts and evolved through horizontal transfer and gene loss.

Tandemly duplicated MYB genes specifically in the Phaseoleae lineage are functionally diverged in the regulation of anthocyanin biosynthesis

The paper investigates functional divergence of tandemly duplicated MYB genes in soybean, showing they regulate anthocyanin biosynthesis differently in various tissues.

The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation

This study identifies the molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation by analyzing cleavage specificity across species.

Eosinophils exert direct and indirect anti-tumorigenic effects in the development of esophageal squamous cell carcinoma

This study shows eosinophils reduce esophageal squamous cell carcinoma by releasing reactive oxygen species and inhibiting IL-17 pathways.

Endoplasmic-Reticulum stress controls PIN-LIKES abundance and thereby growth adaptation

The paper shows that ER stress affects PILS protein abundance, linking it to growth adaptation in Arabidopsis under environmental stress.

ScRNA-seq of Diverse Pheochromocytoma Patients Reveals Distinct Microenvironment Characteristics and Supports an Informative Molecular Classification System

This study uses scRNA-seq to classify PCCs into metabolism-type and kinase-type based on molecular features and microenvironment characteristics, suggesting potential therapeutic strategies.

PD1 is transcriptionally regulated by LEF1 in mature T cells

This study shows LEF1, not TCF1, regulates PD1 transcription in mature T cells, with implications for cancer immunotherapy.

Structural basis of histone H2A lysine 119 deubiquitination by Polycomb Repressive Deubiquitinase BAP1/ASXL1

This study reveals the molecular mechanism of nucleosomal H2AK119Ub deubiquitination by human BAP1/ASXL1 and explains how cancer mutations disrupt this process.

Amino acid transporter SLC7A5 regulates Paneth cell function to affect the intestinal inflammatory response

This study shows that SLC7A5 regulates Paneth cell function, affecting intestinal inflammation and cell proliferation through mTORC1 signaling.

Modulating the epigenetic state promotes the reprogramming of transformed cells to pluripotency in a line-specific manner

This study identifies line-specific barriers to reprogramming transformed cells and shows that MEK inhibition can overcome some of these barriers by modulating the epigenetic state.

Optimization of host cell-compatible, antimicrobial peptides effective against biofilms and clinical isolates of drug-resistant bacteria.

This study optimizes antimicrobial peptides to enhance activity against drug-resistant bacteria and biofilms while reducing cytotoxicity.

Antifungal tolerance and resistance emerge at distinct drug concentrations and rely upon different aneuploid chromosomes

This study identifies that antifungal drug tolerance and resistance in Candida albicans emerge at different drug concentrations and are associated with distinct aneuploid chromosomes.

Gut microbiota assemblages of generalist predators are driven by local- and landscape-scale factors

This study examines how environmental factors shape spider gut microbiota composition using high-throughput sequencing, identifying local and landscape-scale drivers.

Minimal cell JCVI-syn3B as a chassis to reveal the mechanisms behind Mycoplasma host-pathogen interactions

The paper investigates host-mycoplasma interactions using minimized Mycoplasma mycoides strains, identifying genes essential for attachment but not parasitism.

Statistical learning of large-scale genetic data: How to run a genome-wide association study of gene-expression data using the 1000 GenomesProject data

The paper describes a workshop teaching students to perform GWAS on gene expression data using the 1000 Genomes Project, resulting in ~1.4 million p-values and enhancing statistical learning through real-world applications.

Chemoenzymatic Synthesis of Heparan Sulfate Oligosaccharides having a Domain Structure

This study develops a chemoenzymatic method to synthesize HS oligosaccharides with defined NS and NA domains, showing that NA domain length affects chemokine binding.

Development of allosteric, selective cyclin-dependent kinase 2 (CDK2) inhibitors that are negatively cooperative with cyclin binding and show potential as contraceptive agents

This paper develops high-affinity, structurally confirmed allosteric CDK2 inhibitors that show negative cooperativity with cyclin binding and demonstrate contraceptive potential in mouse testicular explants.

CARD8 negatively regulates NLRP1 inflammasome activation level by interaction with NLRP1

This study shows that the T60 variant of CARD8 inhibits NLRP1 inflammasome activation by interacting with NLRP1 and preventing inflammasome assembly.

Dominant constraints on the evolution of rhythmic gene expression

This study identifies common rhythmic gene expression patterns across species and shows that energetic costs constrain their evolution through computational simulations.

DNA metabarcoding of gut contents reveals key habitat and seasonal drivers of trophic networks involving generalist predators in agricultural landscapes

This study uses DNA metabarcoding to analyze gut contents of spiders in agricultural landscapes, revealing how environmental factors influence their trophic interactions and diet composition.

PILS proteins provide a homeostatic feedback on auxin signaling output

This study identifies GASP1 as a regulator of PILS6 protein abundance, showing that it modulates auxin signaling output through homeostatic feedback.

Biophysical, Molecular and Proteomic profiling of Human Retinal Organoids derived Exosomes

This study characterizes the biophysical, molecular, and proteomic properties of EVs from retinal organoids and compares them to hUCMSC EVs, showing superior therapeutic potential for retinal disorders.

Rational design by structural biology of industrializable, long-acting antihyperglycemic GLP-1 receptor agonists

The paper designs long-acting GLP-1 receptor agonists using structural biology to prevent DPP-4 degradation while maintaining receptor binding, achieving hypoglycemic effects lasting over 24 hours.

Bumblebees retrieve only the ordinal ranking of foraging options when comparing memories obtained in distinct settings

This study shows bumblebees use only ordinal memory of foraging options, not absolute reward values, when making decisions in novel pairings.

A dual mechanism of APC/C inhibition by MAP kinases

This study identifies two MAPK pathways that inhibit APC/C activity during mitotic arrest in fission yeast, clarifying their role in spindle checkpoint activation and chromosome segregation.