N. Udeshi

Automated single-cell proteomics providing sufficient proteome depth to study complex biology beyond cell type classifications

This study presents an automated single-cell proteomics workflow that identifies over 4,000 proteins per cell and detects key regulatory proteins in LPS-perturbed THP-1 cells.

Structural basis for recognition of unfolded proteins by the ER stress sensor ERN1/IRE1α

This study identifies a 7-residue motif in unfolded proteins recognized by IRE1LD, revealing how IRE1 detects misfolded proteins to trigger the UPR.

Sensitive, high-throughput HLA-I and HLA-II immunopeptidomics using parallel accumulation-serial fragmentation mass spectrometry

This paper develops a high-throughput, sensitive MS-based immunopeptidomics workflow to identify HLA-I and HLA-II peptides from tumor samples, achieving improved coverage with reduced sample requirements.

Dual Functions of SPOP and ERG Dictate Androgen Therapy Responses in Prostate Cancer

This study shows that SPOP and ERG mutations in prostate cancer have opposing effects on androgen receptor signaling and therapy response.

CBL mutations promote activation of PI3K/AKT signaling via LYN kinase

The paper investigates how CBL mutations drive oncogenesis by enhancing LYN kinase activity and PI3K/AKT signaling, suggesting LYN inhibition as a therapeutic strategy.