Structural dynamics of cytochrome P450 3A4 in the presence of substrates and cytochrome P450 reductase
J. Ducharme, I. F. Sevrioukova, C. Thibodeaux, K. Auclair
This study uses HDX-MS to show that CYP3A4 rigidifies upon binding substrates or CPR, affecting conformational dynamics and suggesting allostery mechanisms.
bioRxiv · Mar 9, 2021Biochemistry